- 专利标题： BIFUNCTIONAL CHEMICAL EPIGENENTIC MODIFIERS AND METHODS OF USE
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申请号： US18438385申请日： 2024-02-09
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公开(公告)号： US20240287492A1公开(公告)日： 2024-08-29
- 发明人: Nate Hathaway , Jian Jin , Kyle Butler , Anna Chiarella
- 申请人： The University of North Carolina at Chapel Hill
- 申请人地址： US NC Chapel Hill
- 专利权人： The University of North Carolina at Chapel Hill
- 当前专利权人： The University of North Carolina at Chapel Hill
- 当前专利权人地址： US NC Chapel Hill
- 主分类号： C12N9/90
- IPC分类号： C12N9/90 ; A61K31/167 ; A61K31/436 ; A61K38/15 ; A61K47/55 ; C07K14/47 ; C12N9/22 ; C12N15/11
摘要：
The present disclosure relates to bifunctional chemical epigenetic modifiers, and methods of making, kits and using the bifunctional chemical epigenetic modifiers. The bifunctional chemical epigenetic modifiers can include a FK506 molecule or derivative thereof, a linker and a bifunctional ligand. The bifunctional ligand can be a histone deacetylase inhibitor.
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