![(1H-PYRROLO[2,3-B]PYRIDIN-1-YL)PYRIMIDIN-2-YL-AMINO-PHENYL-ACRYLAMIDE INHIBITORS OF EGFR FOR USE IN THE TREATMENT OF BRAIN TUMORS](/docs/US/2024-09-05/US20240293405A1/abs.jpg.600x600.jpg)
- 专利标题： (1H-PYRROLO[2,3-B]PYRIDIN-1-YL)PYRIMIDIN-2-YL-AMINO-PHENYL-ACRYLAMIDE INHIBITORS OF EGFR FOR USE IN THE TREATMENT OF BRAIN TUMORS
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申请号： US18573473申请日： 2022-06-22
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公开(公告)号： US20240293405A1公开(公告)日： 2024-09-05
- 发明人: Jean J. Zhao , William Kerns
- 申请人： Jean ZHAO , William KERNS , Dana-Farber Cancer Institute, Inc. , Crimson Biopharm Inc.
- 申请人地址： US MA Brookline
- 专利权人： Jean ZHAO,William KERNS,Dana-Farber Cancer Institute, Inc.,Crimson Biopharm Inc.
- 当前专利权人： Jean ZHAO,William KERNS,Dana-Farber Cancer Institute, Inc.,Crimson Biopharm Inc.
- 当前专利权人地址： US MA Brookline
- 国际申请： PCT/US22/34574 2022.06.22
- 进入国家日期： 2023-12-22
- 主分类号： A61K31/506
- IPC分类号： A61K31/506 ; C07D471/04
![(1H-PYRROLO[2,3-B]PYRIDIN-1-YL)PYRIMIDIN-2-YL-AMINO-PHENYL-ACRYLAMIDE INHIBITORS OF EGFR FOR USE IN THE TREATMENT OF BRAIN TUMORS](/abs-image/US/2024/09/05/US20240293405A1/abs.jpg.150x150.jpg)
摘要：
The invention generally relates to pharmaceuticals and therapeutic methods. More particularly, the invention provides small molecule EGFR inhibitors (e.g., EGFR tyrosine kinase inhibitor compounds) and pharmaceutical compositions thereof, as well as methods of their use in treating various diseases and conditions, such as cancers of the central nervous system (e.g., primary and metastatic brain cancers) and lung cancers.
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