公开(公告)号：US20200268864A1

公开(公告)日：2020-08-27

申请号：US16755636

申请日：2018-10-24

申请人： Jean ZHAO ,  Liya DING ,  Oiwei WANG ,  Hye-Jung KIM ,  Dana-Farber Cancer Institute, Inc.

发明人： Jean Zhao ,  Liya Ding ,  Qiwei Wang ,  Hye-Jung Kim

IPC分类号： A61K39/00 ,  A61K39/39

摘要： The present invention provides a cancer vaccine comprising DNA repair-deficient cancer cells, wherein the cancer cells are contacted with a PARP inhibitor to induce DNA breaks. In another aspect, a method of treating a subject afflicted with a cancer comprising administering to the subject a therapeutically effective amount of a cancer vaccine comprising DNA repair-deficient cancer cells, wherein the cancer cells are contacted with a PARP inhibitor to induce DNA breaks, is provided. The present invention also provides a kit comprising DNA repair-deficient cancer cells modified as described herein, PARP inhibitors, immune checkpoint inhibitors, and combinations thereof, packaged in a suitable container.

公开(公告)号：US08178317B2

公开(公告)日：2012-05-15

申请号：US12150941

申请日：2008-05-01

申请人： Thomas M. Roberts ,  Jean Zhao ,  David E. Hill ,  William C. Hahn ,  Jesse Boehm

发明人： Thomas M. Roberts ,  Jean Zhao ,  David E. Hill ,  William C. Hahn ,  Jesse Boehm

IPC分类号： C12P21/06 ,  C07H21/02

CPC分类号： C12Q1/6886 ,  C07K2319/033 ,  C07K2319/43 ,  C12N15/1079 ,  C12Q2600/178

摘要： Provided herein are nucleic acids, proteins, vectors, cells, kits, devices and methods useful for identifying regulatable proteins that are able to complement components of cellular signaling pathways. Also provided are compositions and methods using these complementing genes directly as markers for cancer diagnosis or prognosis and as targets for anti-neoplastic therapeutics. Further provided are methods for using changes caused by expression of the complementing genes to indirectly identify associated genes to be used as markers for cancer diagnosis or prognosis and as targets for anti-neoplastic therapeutics.

摘要翻译： 本文提供的核酸，蛋白质，载体，细胞，试剂盒，装置和方法可用于鉴定能补充细胞信号通路成分的可调节蛋白质。 还提供了使用这些互补基因直接作为癌症诊断或预后的标志物和作为抗肿瘤治疗剂的靶标的组合物和方法。 进一步提供的是使用由互补基因的表达引起的变化间接鉴定用作癌症诊断或预后的标志物和作为抗肿瘤治疗剂靶标的相关基因的方法。

公开(公告)号：US20050282456A1

公开(公告)日：2005-12-22

申请号：US10870763

申请日：2004-06-17

申请人： Jean Zhao ,  Kathleen Jividen ,  Gary Gilbertson ,  Brian Gray

发明人： Jean Zhao ,  Kathleen Jividen ,  Gary Gilbertson ,  Brian Gray

IPC分类号： A61F13/15 ,  A61F13/20 ,  A61L15/26 ,  A61L15/62 ,  B32B27/12 ,  B32B27/36 ,  D04H1/00

CPC分类号： A61F13/15211 ,  A61F13/514 ,  A61L15/26 ,  A61L15/62 ,  D04H1/587 ,  Y10T442/674 ,  Y10T442/675 ,  Y10T442/696 ,  C08L67/04

摘要： A laminate that is useful as a flushable, fluid impervious backsheet for flushable absorbent articles. The laminate includes a polyhydroxyalkanoate copolymer and a nonwoven. The flushable absorbent article includes a fluid permeable topsheet, absorbent core, and a flushable fluid impervious backsheet including the same laminate.

摘要翻译： 一种可用作可冲洗的可流体渗透的底片用于可冲洗的吸收制品的层压材料。 层压材料包括聚羟基链烷酸酯共聚物和无纺布。 可冲洗的吸收制品包括流体可渗透的顶片，吸收芯和包括相同层压体的可冲洗不透液体的底片。

公开(公告)号：US20240293405A1

公开(公告)日：2024-09-05

申请号：US18573473

申请日：2022-06-22

申请人： Jean ZHAO ,  William KERNS ,  Dana-Farber Cancer Institute, Inc. ,  Crimson Biopharm Inc.

发明人： Jean J. Zhao ,  William Kerns

IPC分类号： A61K31/506 ,  C07D471/04

CPC分类号： A61K31/506 ,  C07D471/04

摘要： The invention generally relates to pharmaceuticals and therapeutic methods. More particularly, the invention provides small molecule EGFR inhibitors (e.g., EGFR tyrosine kinase inhibitor compounds) and pharmaceutical compositions thereof, as well as methods of their use in treating various diseases and conditions, such as cancers of the central nervous system (e.g., primary and metastatic brain cancers) and lung cancers.

公开(公告)号：US20090047675A1

公开(公告)日：2009-02-19

申请号：US12150941

申请日：2008-05-01

申请人： Thomas M. Roberts ,  Jean Zhao ,  David E. Hill ,  William C. Hahn ,  Jesse Boehm

发明人： Thomas M. Roberts ,  Jean Zhao ,  David E. Hill ,  William C. Hahn ,  Jesse Boehm

IPC分类号： C12N5/06 ,  C12Q1/68

CPC分类号： C12Q1/6886 ,  C07K2319/033 ,  C07K2319/43 ,  C12N15/1079 ,  C12Q2600/178

摘要： Provided herein are nucleic acids, proteins, vectors, cells, kits, devices and methods useful for identifying regulatable proteins that are able to complement components of cellular signaling pathways. Also provided are compositions and methods using these complementing genes directly as markers for cancer diagnosis or prognosis and as targets for anti-neoplastic therapeutics. Further provided are methods for using changes caused by expression of the complementing genes to indirectly identify associated genes to be used as markers for cancer diagnosis or prognosis and as targets for anti-neoplastic therapeutics.

摘要翻译： 本文提供的核酸，蛋白质，载体，细胞，试剂盒，装置和方法可用于鉴定能补充细胞信号通路成分的可调节蛋白质。 还提供了使用这些互补基因直接作为癌症诊断或预后的标志物和作为抗肿瘤治疗剂的靶标的组合物和方法。 进一步提供的是使用由互补基因的表达引起的变化间接鉴定用作癌症诊断或预后的标志物和作为抗肿瘤治疗剂靶标的相关基因的方法。