专利检索 ap:"Crimson Biopharm Inc." 第 1 页

1.

发明公开
CRYSTALLINE POLYMORPHS OF EPIDERMAL GROWTH FACTOR RECEPTOR INHIBITOR, AND COMPOSITIONS AND METHODS THEREOF 审中-公开

公开(公告)号：US20240239796A1

公开(公告)日：2024-07-18

申请号：US18574248

申请日：2022-07-05

申请人： Crimson BioPharm Inc.

发明人： Jean Zhao , Xudong Wei , Jane Zheng Li , Ruiping Wang

IPC分类号： C07D471/04 , A61K31/506 , C07C309/29

CPC分类号： C07D471/04 , A61K31/506 , C07C309/29 , C07B2200/13

摘要： Provided herein are crystalline Forms (or polymorphs) I, II, III, IV, V, VI, and VII of N-(5-((4-(1H-pyrrolo[2,3-b]pyridin-1-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide tosylate salt and methods of inhibiting the activity of EGFR or treating a disease mediated by EGFR by using an effective amount of at least one crystalline form described herein.

2.

发明公开
(1H-PYRROLO[2,3-B]PYRIDIN-1-YL)PYRIMIDIN-2-YL-AMINO-PHENYL-ACRYLAMIDE INHIBITORS OF EGFR FOR USE IN THE TREATMENT OF BRAIN TUMORS 审中-公开

公开(公告)号：US20240293405A1

公开(公告)日：2024-09-05

申请号：US18573473

申请日：2022-06-22

申请人： Jean ZHAO , William KERNS , Dana-Farber Cancer Institute, Inc. , Crimson Biopharm Inc.

发明人： Jean J. Zhao , William Kerns

IPC分类号： A61K31/506 , C07D471/04

CPC分类号： A61K31/506 , C07D471/04

摘要： The invention generally relates to pharmaceuticals and therapeutic methods. More particularly, the invention provides small molecule EGFR inhibitors (e.g., EGFR tyrosine kinase inhibitor compounds) and pharmaceutical compositions thereof, as well as methods of their use in treating various diseases and conditions, such as cancers of the central nervous system (e.g., primary and metastatic brain cancers) and lung cancers.