发明公开
- 专利标题： INHIBITORS OF DNA-DEPENDENT PROTEIN KINASE AND COMPOSITIONS AND USES THEREOF
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申请号： US18287227申请日： 2022-04-15
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公开(公告)号： US20240300977A1公开(公告)日： 2024-09-12
- 发明人: Micah Maetani , Xin Jenny Xie , Anthony Forget , Aaron Prodeus , Stephanie Yazinski , Rubina Giare Parmar
- 申请人： Intellia Therapeutics, Inc.
- 申请人地址： US MA Cambridge
- 专利权人： Intellia Therapeutics, Inc.
- 当前专利权人： Intellia Therapeutics, Inc.
- 当前专利权人地址： US MA Cambridge
- 国际申请： PCT/US22/25075 2022.04.15
- 进入国家日期： 2023-10-17
- 主分类号： C07D519/00
- IPC分类号： C07D519/00 ; C12N5/071 ; C12N5/0783 ; C12N9/22 ; C12N15/113 ; C12N15/90
摘要：
The present disclosure relates to inhibitors of DNA protein kinase, and compositions and methods of use thereof. In some embodiments, the inhibitors have the structure of Formula I:
or a salt thereof,
wherein:
x1 is C—R3 or N;
R1 is C1-C3 alkyl;
R2 is cycloalkyl or heterocyclyl, and cycloalkyl and heterocyclyl are optionally substituted with one or more R6;
R3 is H or C1-C3 alkyl;
R4 is H or C1-C3 alkyl;
R5 is C1-C3 alkyl;
each R6 is independently selected from hydroxy, halo, alkyl, alkoxy, cycloalkyl, amino, and cyano, or two R6, taken together with the atom or atoms to which they are bonded, form a spirocyclic or fused ring; and
R7 is H or C1-C3 alkyl.
or a salt thereof,
wherein:
x1 is C—R3 or N;
R1 is C1-C3 alkyl;
R2 is cycloalkyl or heterocyclyl, and cycloalkyl and heterocyclyl are optionally substituted with one or more R6;
R3 is H or C1-C3 alkyl;
R4 is H or C1-C3 alkyl;
R5 is C1-C3 alkyl;
each R6 is independently selected from hydroxy, halo, alkyl, alkoxy, cycloalkyl, amino, and cyano, or two R6, taken together with the atom or atoms to which they are bonded, form a spirocyclic or fused ring; and
R7 is H or C1-C3 alkyl.
公开/授权文献
- US1653566A Cushion for creels or jacks 公开/授权日：1927-12-20
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