A handheld medical diagnostic device integrates at least seven sensor modules, including a high-magnification camera, otoscope camera, stethoscope, infrared thermometer, EKG, pulse oximeter, body composition monitor, glucometer, and/or hematology analyzer. The device features a system-on-chip (SoC) processor for intelligent data management, edge computing, and cloud-based AI processing, while applying privacy-preserving techniques. A wireless transceiver enables data transmission and reception between the sensors, edge compute nodes, and cloud platforms. The ergonomically designed housing includes a display with a force-sensitive layer for user input and navigation. The high-magnification camera module offers 300× magnification for visualizing blood cells and skin, with an annular LED array, encryption engine, and physically unclonable function (PUF) circuit. The otoscope camera module features a narrow profile for ear, nose, and throat imaging, with an annular LED array.