Invention Application
- Patent Title: SMALL MOLECULE INHIBITORS OF UBIQUITIN SPECIFIC PROTEASE 1 (USP1) AND USES THEREOF
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Application No.: US18708686Application Date: 2022-11-11
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Publication No.: US20250066348A1Publication Date: 2025-02-27
- Inventor: Jianping Wu , Luoheng QIN , Jinxin LIU
- Applicant: INSILICO MEDICINE IP LIMITED
- Applicant Address: CN Central Hong Kong
- Assignee: INSILICO MEDICINE IP LIMITED
- Current Assignee: INSILICO MEDICINE IP LIMITED
- Current Assignee Address: CN Central Hong Kong
- Priority: WOPCT/CN2021/130284 20211112,WOPCT/CN2022/123821 20221008
- International Application: PCT/CN2022/131290 WO 20221111
- Main IPC: C07D471/04
- IPC: C07D471/04 ; A61K31/506 ; A61K31/519 ; A61K31/52 ; C07D487/04

Abstract:
Provided herein are small molecules inhibitory compounds of ubiquitin specific protease 1 (USP1) and compositions comprising the same. Further provided herein are methods for targeting ubiquitin specific protease 1 (USP1) and methods of treating diseases or disorders related to USP1, such as cancer.
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