公开(公告)号：US20250034133A1

公开(公告)日：2025-01-30

申请号：US18708755

申请日：2022-11-11

Applicant: INSILICO MEDICINE IP LIMITED

Inventor： Jianping Wu ,  Luoheng QIN ,  Jinxin LIU ,  Yingtao LIU

IPC: C07D471/04 ,  A61K31/519 ,  A61K31/5383 ,  A61K31/542 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04

Abstract: Provided are small molecules inhibitory compounds of ubiquitin specific protease 1 (USP1) and compositions comprising the same. Further provided are methods for targeting ubiquitin specific protease 1 (USP1) and methods of treating diseases or disorders related to USP1, such as cancers.

公开(公告)号：US20240166608A1

公开(公告)日：2024-05-23

申请号：US18529689

申请日：2023-12-05

Applicant: Insilico Medicine IP Limited

Inventor： Xiao DING ,  Jinxin LIU ,  Feng REN ,  Jianfei WAN ,  Wei ZHU

IPC: C07D231/56 ,  A61P35/00 ,  C07D209/44 ,  C07D215/14 ,  C07D401/04 ,  C07D403/08 ,  C07D471/04 ,  C07D487/04

CPC classification number: C07D231/56 ,  A61P35/00 ,  C07D209/44 ,  C07D215/14 ,  C07D401/04 ,  C07D403/08 ,  C07D471/04 ,  C07D487/04

Abstract: The disclosure provides for compounds and methods for modulating or inhibiting TEAD. Further provided herein are pharmaceutical compositions comprising the TEAD inhibitors and methods of treatment using the TEAD inhibitors or the pharmaceutical compositions.

公开(公告)号：US20250066348A1

公开(公告)日：2025-02-27

申请号：US18708686

申请日：2022-11-11

Applicant: INSILICO MEDICINE IP LIMITED

Inventor： Jianping Wu ,  Luoheng QIN ,  Jinxin LIU

IPC: C07D471/04 ,  A61K31/506 ,  A61K31/519 ,  A61K31/52 ,  C07D487/04

Abstract: Provided herein are small molecules inhibitory compounds of ubiquitin specific protease 1 (USP1) and compositions comprising the same. Further provided herein are methods for targeting ubiquitin specific protease 1 (USP1) and methods of treating diseases or disorders related to USP1, such as cancer.

公开(公告)号：US20250026754A1

公开(公告)日：2025-01-23

申请号：US18709234

申请日：2022-11-11

Applicant: INSILICO MEDICINE IP LIMITED

Inventor： Jianping Wu ,  Luoheng QIN ,  Jinxin LIU

IPC: C07D471/04 ,  A61K31/444 ,  A61K31/506 ,  A61P35/00

Abstract: Provided are small molecules inhibitory compounds of ubiquitin specific protease 1 (USP1) and compositions comprising the same. Provided are methods for targeting ubiquitin specific protease 1 (USP1) and methods of treating diseases or disorders related to USP1, such as cancer.