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公开(公告)号:US20250034133A1
公开(公告)日:2025-01-30
申请号:US18708755
申请日:2022-11-11
Applicant: INSILICO MEDICINE IP LIMITED
Inventor: Jianping Wu , Luoheng QIN , Jinxin LIU , Yingtao LIU
IPC: C07D471/04 , A61K31/519 , A61K31/5383 , A61K31/542 , C07D487/04 , C07D498/04 , C07D513/04
Abstract: Provided are small molecules inhibitory compounds of ubiquitin specific protease 1 (USP1) and compositions comprising the same. Further provided are methods for targeting ubiquitin specific protease 1 (USP1) and methods of treating diseases or disorders related to USP1, such as cancers.
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公开(公告)号:US20250066348A1
公开(公告)日:2025-02-27
申请号:US18708686
申请日:2022-11-11
Applicant: INSILICO MEDICINE IP LIMITED
Inventor: Jianping Wu , Luoheng QIN , Jinxin LIU
IPC: C07D471/04 , A61K31/506 , A61K31/519 , A61K31/52 , C07D487/04
Abstract: Provided herein are small molecules inhibitory compounds of ubiquitin specific protease 1 (USP1) and compositions comprising the same. Further provided herein are methods for targeting ubiquitin specific protease 1 (USP1) and methods of treating diseases or disorders related to USP1, such as cancer.
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公开(公告)号:US11739077B2
公开(公告)日:2023-08-29
申请号:US18106339
申请日:2023-02-06
Applicant: Insilico Medicine IP Limited
Inventor: Jianping Wu , Luoheng Qin , Jinxin Liu
IPC: C07D401/14 , A61P35/00
CPC classification number: C07D401/14 , A61P35/00
Abstract: The disclosure provides for small molecules inhibitory compounds of ubiquitin specific protease 1 (USP1) and compositions comprising the same. The disclosure further provides methods for targeting ubiquitin specific protease 1 (USP1) and methods of treating diseases or disorders related to USP1, such as cancer.
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公开(公告)号:US20230183210A1
公开(公告)日:2023-06-15
申请号:US18106339
申请日:2023-02-06
Applicant: Insilico Medicine IP Limited
Inventor: Jianping Wu , Luoheng Qin , Jinxin Liu
IPC: C07D401/14 , A61P35/00
CPC classification number: C07D401/14 , A61P35/00
Abstract: The disclosure provides for small molecules inhibitory compounds of ubiquitin specific protease 1 (USP1) and compositions comprising the same. The disclosure further provides methods for targeting ubiquitin specific protease 1 (USP1) and methods of treating diseases or disorders related to USP1, such as cancer.
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公开(公告)号:US20250026754A1
公开(公告)日:2025-01-23
申请号:US18709234
申请日:2022-11-11
Applicant: INSILICO MEDICINE IP LIMITED
Inventor: Jianping Wu , Luoheng QIN , Jinxin LIU
IPC: C07D471/04 , A61K31/444 , A61K31/506 , A61P35/00
Abstract: Provided are small molecules inhibitory compounds of ubiquitin specific protease 1 (USP1) and compositions comprising the same. Provided are methods for targeting ubiquitin specific protease 1 (USP1) and methods of treating diseases or disorders related to USP1, such as cancer.
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公开(公告)号:US20240190839A1
公开(公告)日:2024-06-13
申请号:US18340978
申请日:2023-06-26
Applicant: Insilico Medicine IP Limited
Inventor: Jianping Wu , Luoheng Qin , Jinxin Liu
IPC: C07D401/14 , A61P35/00
CPC classification number: C07D401/14 , A61P35/00
Abstract: The disclosure provides for small molecules inhibitory compounds of ubiquitin specific protease 1 (USP1) and compositions comprising the same. The disclosure further provides methods for targeting ubiquitin specific protease 1 (USP1) and methods of treating diseases or disorders related to USP1, such as cancer.
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