A method of making paint contains steps of a first-time/second fermentation. Graphene mother bacteria are added to warm water and are placed in a temperature-controlled room for two days to cultivate bacteria. Then, the steps of the first-time/second fermentation include: i) pouring the graphene mother bacteria, edible powders, and powdered sugars into a container, then adding the warm waters into the container; ii) crushing the graphene fermentation clump evenly by using a crush tool to produce crushed graphene fermentation pieces, spreading the crushed graphene fermentation pieces on a stainless steel platform and placing the crushed graphene fermentation pieces in the temperature-controlled room to dry for three to four days; iii) putting the enzyme product into a mixer so as to stir and refine the enzyme product into enzyme powders. After finishing the first-time fermentation, the steps i) to iii) are repeated to complete the steps of the second-time fermentation.