In some aspects, the present disclosure pertains to systems for forming hydrogel compositions, the systems comprising a first reservoir containing an iodinated polymer composition that comprise an iodinated polymer having multiple cyclic imide ester groups, a second reservoir containing a buffered diluent solution having a first pH that comprises water, a first buffering agent and a polyamine compound, and a third reservoir containing a buffered accelerant solution having a second pH that is higher than the first pH and comprises water and a second buffering agent. Other aspects of the present disclosure pertain to methods of using such systems for forming hydrogel compositions.