公开(公告)号：US20240335568A1

公开(公告)日：2024-10-10

申请号：US18627837

申请日：2024-04-05

Applicant: Boston Scientific Scimed, Inc.

Inventor： Yen-Hao Hsu ,  Joseph Thomas Delaney, JR. ,  Cristian Parisi ,  Heather Cirka ,  Alexis Compton

IPC: A61K49/04

CPC classification number: A61K49/0438 ,  A61K49/0457 ,  A61K49/0495

Abstract: In some aspects, the present disclosure pertains to radiopaque hydrogel compositions that comprise a radiopaque polysaccharide that comprises a plurality of radiopaque moieties that are covalently linked to a carboxylic-acid-containing polysaccharide along a backbone of the carboxylic-acid-containing polysaccharide. In some aspects, the present disclosure pertains to radiopaque hydrogel compositions that comprise a carboxylate-anion-containing polysaccharide that is ionically crosslinked by multivalent cations. In other aspects, the present disclosure pertains to kits that contain such radiopaque hydrogel compositions, to methods of treatment that comprise administering such radiopaque hydrogel compositions to patients, and to methods of making such radiopaque hydrogel compositions.

公开(公告)号：US20250128220A1

公开(公告)日：2025-04-24

申请号：US18918996

申请日：2024-10-17

Applicant: Boston Scientific Scimed, Inc.

Inventor： Yen-Hao Hsu ,  Heather Cirka ,  Marc Plourde ,  Alexis Compton ,  Anthony Hannan

IPC: B01F35/71 ,  A61K9/00 ,  A61K47/10 ,  A61K47/18 ,  A61L27/02 ,  A61L27/18 ,  A61L27/52 ,  B01F21/00 ,  B01F21/20 ,  B01F23/40 ,  B01F23/451 ,  B01F31/65 ,  B01F101/00

Abstract: In some aspects, the present disclosure pertains to systems for forming hydrogel compositions, the systems comprising a first reservoir containing an iodinated polymer composition that comprise an iodinated polymer having multiple cyclic imide ester groups, a second reservoir containing a buffered diluent solution having a first pH that comprises water, a first buffering agent and a polyamine compound, and a third reservoir containing a buffered accelerant solution having a second pH that is higher than the first pH and comprises water and a second buffering agent. Other aspects of the present disclosure pertain to methods of using such systems for forming hydrogel compositions.