-
公开(公告)号：US20250017956A1
公开(公告)日：2025-01-16
申请号：US18762216
申请日：2024-07-02
Applicant: Boston Scientific Scimed, Inc.
Inventor： Yen-Hao Hsu , Joseph Thomas Delaney, JR. , Rick Dorn , Cristian Parisi , Niraj Gurung , Claire Hobbs
IPC: A61K31/765 , A61K45/06 , C08J3/075 , C08K3/011
Abstract: Disclosed herein are radiopaque, reactive multi-arm polymers that comprise an iodine-containing core region, a plurality of polymer arms comprising a plurality of polymer segments linked to the iodine-containing core region, and a plurality of reactive moieties linked to the plurality of polymer segments. Also disclosed are methods of forming such radiopaque, reactive multi-arm polymers, systems for forming hydrogel compositions that comprise (a) such radiopaque, reactive multi-arm polymers and (b) multifunctional crosslinking compounds comprising a plurality of complementary reactive moieties that are reactive with the reactive moieties of the radiopaque, reactive multi-arm polymers, as well as reaction products of such systems and methods of treatment using such systems.
-
公开(公告)号：US20250000954A1
公开(公告)日：2025-01-02
申请号：US18754776
申请日：2024-06-26
Applicant: Boston Scientific Scimed, Inc.
Inventor： Heather Cirka , Yen-Hao Hsu , Marc Plourde , Joseph Thomas Delaney, JR. , Cristian Parisi
Abstract: Systems for hydrogel hydrolysis as well as methods for hydrogel hydrolysis are disclosed. An example system may include a syringe barrel having a needle connector disposed thereon. A hydrogel hydrolysis material may be disposed in the syringe barrel. The hydrogel hydrolysis material may be configured to be injected into a hydrogel formed in the body of a patient in order to accelerate the hydrolysis of the hydrogel.
-
公开(公告)号：US20240293572A1
公开(公告)日：2024-09-05
申请号：US18590582
申请日：2024-02-28
Applicant: Boston Scientific Scimed, Inc.
Inventor： Yen-Hao Hsu , Cristian Parisi , Joseph Thomas Delaney, JR.
CPC classification number: A61K47/6903 , A61K47/61 , A61K47/64
Abstract: In some aspects, the present disclosure provides therapeutic-agent-releasing polyamino compounds that comprise a polyamino moiety that is covalently linked to a residue of a hydroxyl-substituted therapeutic agent by an ester bond. In various embodiments, such therapeutic-agent-releasing polyamino compounds are used to form therapeutic-agent-releasing hydrogels. In other aspects, the present disclosure provides therapeutic-agent-releasing polysaccharides that comprise a plurality of hydroxyl-substituted therapeutic agent residues that are covalently linked to a carboxylic-acid-containing polysaccharide along a backbone of the carboxylic-acid-containing polysaccharide.
-
公开(公告)号：US20250049964A1
公开(公告)日：2025-02-13
申请号：US18796777
申请日：2024-08-07
Applicant: Boston Scientific Scimed, Inc.
Inventor： Yen-Hao Hsu , Nicolas Ball-Jones , Sasha Viola Rios , Joseph Thomas Delaney, JR. , Cristian Parisi
IPC: A61K49/04
Abstract: In some aspects, the present disclosure pertains to an injectable hydrogel that comprises (a) one or more types of polymeric hydrogen bond donors, (b) one or more types of polymeric hydrogen bond acceptors and (c) water. Other aspects of the present disclosure pertain to kits that comprise a delivery device and one or more containers that contain an injectable hydrogel that comprises one or more types of polymeric hydrogen bond donors, one or more types of polymeric hydrogen bond acceptors, and water. Further aspects of the present disclosure pertain to medical procedures that comprise administering to a subject an injectable hydrogel that comprises one or more types of polymeric hydrogen bond donors, one or more types of polymeric hydrogen bond acceptors, and water.
-
公开(公告)号：US20240390527A1
公开(公告)日：2024-11-28
申请号：US18670474
申请日：2024-05-21
Applicant: Boston Scientific Scimed, Inc.
Inventor： Yen-Hao Hsu , Sasha Viola Rios , Nicolas Ball-Jones , Joseph Thomas Delaney, JR. , Cristian Parisi
IPC: A61K49/04
Abstract: In some aspects the present disclosure provides a radiopaque, reactive copolymer comprising at least one hydrophilic polymer segment having a plurality of hydrophilic polymer segment ends, a plurality of iodinated polymer segments covalently linked to the plurality of hydrophilic polymer segment ends, and a plurality of reactive moieties covalently linked to the iodinated polymer segments. In other aspects, the present disclosure pertains to a system for forming a hydrogel composition that comprises (a) such a radiopaque, reactive copolymer and (b) a nucleophilic compound, as well as to a crosslinked reaction product of the same. In further aspects, the present disclosure pertains to a method of treatment comprising administering to a subject a mixture that comprises (a) such a radiopaque, reactive copolymer and (b) a nucleophilic compound, under conditions such that the nucleophilic compound and the radiopaque, reactive copolymer crosslink after administration.
-
Patent Agency Ranking
公开(公告)号：US20240301179A1
公开(公告)日：2024-09-12
申请号：US18591870
申请日：2024-02-29
Applicant: Boston Scientific Scimed, Inc.
Inventor： Yen-Hao Hsu , Cristian Parisi , Joseph Thomas Delaney, JR.
IPC: C08L5/08 , A61K9/06 , A61K47/36 , A61L27/18 , A61L27/20 , A61L27/50 , A61L27/52 , A61L27/58 , C08J3/075
CPC classification number: C08L5/08 , A61K9/06 , A61K47/36 , A61L27/18 , A61L27/20 , A61L27/50 , A61L27/52 , A61L27/58 , C08J3/075 , C08J2305/08 , C08L2201/06 , C08L2203/02 , C08L2312/00
Abstract: In some aspects, the present disclosure pertains to radiopaque crosslinked hydrogel compositions that comprise a crosslinked reaction product of (a) a polyamino iodinated compound and (b) a reactive polymer that comprises a plurality of reactive groups that are reactive with the amino groups of the polyamino iodinated compound. In other aspects, the present disclosure pertains to systems for forming a hydrogel composition that comprise (a) a polyamino iodinated compound and (b) a reactive polymer that comprises a plurality of reactive groups that are reactive with the amino groups of the polyamino iodinated compound. In further aspects, the present disclosure pertains to methods of treatment using such systems.
-
公开(公告)号：US20240123095A1
公开(公告)日：2024-04-18
申请号：US18469762
申请日：2023-09-19
Applicant: Boston Scientific Scimed, Inc.
Inventor： Yen-Hao Hsu , Joseph Thomas Delaney, JR.
IPC: A61K51/04 , C07D491/18
CPC classification number: A61K51/0446 , C07D491/18
Abstract: In some aspects, the present disclosure pertains to a system for forming a radiopaque product that comprises an iodinated compound comprising one or more diene containing moieties and a multi-arm polymer comprising a plurality of dienophile containing moieties, wherein the diene containing moieties of the iodinated compound couple with the dienophile containing moieties of the multi-arm polymer through a Diels-Alder reaction. Other aspects of the disclosure pertain to crosslinked networks that are formed by combining such an iodinated compound with such a multi-arm polymer, whereupon the diene containing moieties couple with the dienophile containing moieties through a Diels-Alder reaction. Still other aspects of the disclosure pertain to methods of treatment comprising administering to a subject a mixture that comprises such an iodinated compound and such a multi-arm polymer, whereupon the diene containing moieties couple with the dienophile containing moieties by undergoing a Diels-Alder reaction after administration.
-
公开(公告)号：US20230127824A1
公开(公告)日：2023-04-27
申请号：US17972007
申请日：2022-10-24
Applicant: Boston Scientific Scimed Inc.
Inventor： Joseph T. Delaney, JR. , Kolbein Kolste , Tatyana Dyndikova , Yen-Hao Hsu
Abstract: In some embodiments, the present disclosure pertains to systems for forming a hydrogel that comprise (a) a first composition that comprises a polyiodinated polyamino compound and (b) a second composition that comprises a reactive multi-arm polymer that comprises a plurality of hydrophilic polymer arms having reactive end groups that are reactive with the amino groups of the polyiodinated polyamino compound. In some embodiments, the present disclosure pertains to medical hydrogels that are formed by reacting a polyiodinated polyamino compound and a reactive multi-arm polymer that comprises a plurality of hydrophilic polymer arms having reactive end groups that are reactive with the amino groups of the polyiodinated polyamino compound. In some embodiments, the present disclosure pertains to methods of making polyiodinated polyamino compounds.
-
公开(公告)号：US20250064728A1
公开(公告)日：2025-02-27
申请号：US18805710
申请日：2024-08-15
Applicant: Boston Scientific Scimed, Inc.
Inventor： Nicolas Ball-Jones , Joseph Thomas Delaney, JR. , Yen-Hao Hsu , Cristian Parisi
Abstract: In some aspects, the present disclosure provides a system for forming a hydrogel composition that comprises (a) a first reservoir containing a reactive polymer that comprises a plurality of first reactive groups; (b) a second reservoir containing a multifunctional compound that comprises a plurality of second reactive groups, the second reactive groups reacting with the first reactive groups to form covalent bonds at a pH greater than 7.4; and (c) a third reservoir containing a biologically innocuous buffer having a pH in a range of 8 to 12. Other aspects of the present disclosure pertain methods of treatment using such systems.
-
公开(公告)号：US20250059237A1
公开(公告)日：2025-02-20
申请号：US18804679
申请日：2024-08-14
Applicant: Boston Scientific Scimed, Inc.
Inventor： Joseph Thomas Delaney, JR. , Rick Dorn , Yen-Hao Hsu , Cristian Parisi
Abstract: In various aspects, the present disclosure pertains to methods of forming an iodinated peptide compound that comprises: (a) forming a multifunctional precursor compound comprising (i) a residue of an amine-protected peptide that comprises two or more amino acid residues with primary-amine-containing side groups and (ii) a multifunctional moiety linked to the amine-protected peptide residue through an amide group or an ester group; (b) reacting the multifunctional precursor compound in an amide coupling reaction or an esterification coupling reaction with an iodinated compound to form an iodinated, amine-protected peptide compound comprising n iodinated moieties that are covalently attached to the amine-protected peptide residue through a residue of the multifunctional moiety; and (c) deprotecting the iodinated, amine-protected peptide compound to form the iodinated peptide compound.
-
-
-
-
-
-
-
-
-
Search Results
30
records
(took 0.027 seconds)
