发明授权
US3987095A N-substituted-1-(arylsulfinyl and arylsulfonyl)methanesulfonamides
失效
N-取代-1-(芳基磺酰基和芳基磺酰基)甲磺酰胺
- 专利标题: N-substituted-1-(arylsulfinyl and arylsulfonyl)methanesulfonamides
- 专利标题(中): N-取代-1-(芳基磺酰基和芳基磺酰基)甲磺酰胺
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申请号: US465035申请日: 1974-04-29
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公开(公告)号: US3987095A公开(公告)日: 1976-10-19
- 发明人: Christian T. Goralski , Thomas C. Klingler
- 申请人: Christian T. Goralski , Thomas C. Klingler
- 申请人地址: MI Midland
- 专利权人: The Dow Chemical Company
- 当前专利权人: The Dow Chemical Company
- 当前专利权人地址: MI Midland
- 主分类号: C07D295/26
- IPC分类号: C07D295/26 ; C07C143/75 ; A61K31/18 ; C07C143/79
摘要:
The compounds of the formula ##SPC1##In which R independently is hydrogen, lower alkyl, lower alkoxy, halo or trifluoromethyl; x is 1 to 2; n is 1 to 3, and R.sub.1 and R.sub.2 independently are hydrogen, lower alkyl or phenyl and together with the nitrogen atom form a heterocycle which may contain an oxygen atom as a hetero atom. The compounds are prepared by reacting the corresponding N-substituted-1-(arylthio)methanesulfonamide with small, incremental amounts up to substantially equimolar of 30% hydrogen peroxide in glacial acetic acid at 65.degree.-70.degree. C., to obtain the sulfinyl compound, or substantially two equimolar proportions of 30% hydrogen peroxide in glacial acetic acid at reflux temperature to obtain the sulfonyl compound, and recovering the corresponding sulfinyl or sulfonyl product.