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    1-(ARYLTHIO, ARYLSULFINYL AND ARYLSULFONYL)-1,1-DIHALOMETHANESULFONAMIDES
    1.
    发明授权
    1-(ARYLTHIO, ARYLSULFINYL AND ARYLSULFONYL)-1,1-DIHALOMETHANESULFONAMIDES 失效
    1-（ARYLTHIO，ARYLSULFINYL和ARYLSULFONYL）-1,1-二缩水甘油醚

    公开(公告)号：US3946007A

    公开(公告)日：1976-03-23

    申请号：US554953

    申请日：1975-03-03

    申请人： Christian T. Goralski ,  Thomas C. Klingler

    发明人： Christian T. Goralski ,  Thomas C. Klingler

    IPC分类号： C07D211/10 ,  C07D295/26 ,  C07D295/22

    CPC分类号： C07D295/26 ,  C07D211/10

    摘要： The compounds of the formula ##SPC1##In which R is lower alkyl, lower alkoxy or halo, x is an integer from 0 to 2, n is an integer from 0 to 3, Y is halo and R.sub.1 and R.sub.2 independently are hydrogen, lower alkyl, phenyl or substituted phenyl, or, together with the nitrogen atom, form a heterocyclic ring also containing up to one oxygen atom in the heterocycle. The compounds in which x is 0 are prepared by adding chlorine or bromine to a 1-arylthiomethanesulfonamide in the presence of pyridine to form the 1-arylthio-1, 1-dihalomethanesulfonamide. The compounds in which x is 1 or 2 is prepared by adding sodium hypochlorite or sodium hypobromite to a 1-(arylsulfinyl)methane-sulfonamide or a 1-(arylsulfonyl)methanesulfonamide to form the 1-(arylsulfinyl)-1,1-dihalomethanesulfonamide or 1-(arylsulfonyl)-1,1-dihalomethanesulfonamide, respectively. The compounds are useful as antimicrobial agents.

    摘要翻译： 式中R为低级烷基，低级烷氧基或卤素的化合物，x为0至2的整数，n为0至3的整数，Y为卤素，R 1和R 2各为氢，低级烷基，苯基 或取代的苯基，或者与氮原子一起形成在该杂环中也含有至多一个氧原子的杂环。 在吡啶存在下，通过在1-芳基硫代甲磺酰胺中加入氯或溴来制备x为0的化合物，形成1-芳硫基-1,1-二卤代甲磺酰胺。 通过向1-（芳基亚磺酰基）甲磺酰胺或1-（芳基磺酰基）甲磺酰胺中加入次氯酸钠或次溴酸钠，形成1-（芳基亚磺酰基）-1,1-二卤代甲磺酰胺制备x为1或2的化合物 或1-（芳基磺酰基）-1,1-二卤代甲磺酰胺。 这些化合物可用作抗微生物剂。

    N-substituted-1-(arylsulfinyl and arylsulfonyl)methanesulfonamides
    4.
    发明授权
    N-substituted-1-(arylsulfinyl and arylsulfonyl)methanesulfonamides 失效
    N-取代-1-（芳基磺酰基和芳基磺酰基）甲磺酰胺

    公开(公告)号：US3987095A

    公开(公告)日：1976-10-19

    申请号：US465035

    申请日：1974-04-29

    申请人： Christian T. Goralski ,  Thomas C. Klingler

    发明人： Christian T. Goralski ,  Thomas C. Klingler

    IPC分类号： C07D295/26 ,  C07C143/75 ,  A61K31/18 ,  C07C143/79

    CPC分类号： C07D295/26

    摘要： The compounds of the formula ##SPC1##In which R independently is hydrogen, lower alkyl, lower alkoxy, halo or trifluoromethyl; x is 1 to 2; n is 1 to 3, and R.sub.1 and R.sub.2 independently are hydrogen, lower alkyl or phenyl and together with the nitrogen atom form a heterocycle which may contain an oxygen atom as a hetero atom. The compounds are prepared by reacting the corresponding N-substituted-1-(arylthio)methanesulfonamide with small, incremental amounts up to substantially equimolar of 30% hydrogen peroxide in glacial acetic acid at 65.degree.-70.degree. C., to obtain the sulfinyl compound, or substantially two equimolar proportions of 30% hydrogen peroxide in glacial acetic acid at reflux temperature to obtain the sulfonyl compound, and recovering the corresponding sulfinyl or sulfonyl product.