发明授权
- 专利标题: Process for the production of carnitine
- 专利标题(中): 肉碱生产工艺
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申请号: US616849申请日: 1975-09-25
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公开(公告)号: US4018821A公开(公告)日: 1977-04-19
- 发明人: Leander Tenud
- 申请人: Leander Tenud
- 申请人地址: CH Gampel
- 专利权人: Lonza Ltd.
- 当前专利权人: Lonza Ltd.
- 当前专利权人地址: CH Gampel
- 优先权: CH012971/74 19740925
- 主分类号: C07C229/22
- IPC分类号: C07C229/22 ; A61K31/13 ; A61K31/205 ; C07C20060101 ; C07C227/12 ; C07C101/10 ; C07C101/12
摘要:
The process for the production of carnitine hydrochloride which involves placing an ester of .gamma.-halo-acetoacetic acid having the formula: ##STR1## wherein R.sub.1 is hydrogen, R.sub.2 is a lower alkyl group having 1 to 10 carbon atoms and X is a halogen atom selected from the group consisting of chlorine or bromine, in an aqueous solution of excess trimethyl amine held at a temperature between 0.degree. and 50.degree. C., a reaction resulting between said ester and said amine. The excess trimethyl amine is distilled off. The pH of the solution is adjusted between 4 and 8, (3-carbalkoxy-2-oxopropyl)-trimethyl ammonium halide resulting. The (3-carbalkoxy-2-oxopropyl)-trimethyl ammonium is hydrogenated without isolating said halide from solution, a carnitine ester resulting. The carnitine ester is converted by means of aqueous hydrochloric acid into carnitine hydrochloride.
公开/授权文献
- US5189915A Single mode ultrasonic inspection method and apparatus 公开/授权日:1993-03-02
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