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33 条记录 (耗时 0.014 秒)

    Fluorodesulfurization of alkyl mercaptans or alkyl dithianes
    1.
    发明授权
    Fluorodesulfurization of alkyl mercaptans or alkyl dithianes 失效
    烷基硫醇或烷基二噻烷的脱硫

    公开(公告)号：US4049708A

    公开(公告)日：1977-09-20

    申请号：US663586

    申请日：1976-03-04

    申请人： Janos Kollonitsch ,  Stephen Marburg

    发明人： Janos Kollonitsch ,  Stephen Marburg

    IPC分类号： C07C227/16 ,  C07C101/10 ,  A61K31/195

    CPC分类号： C07C227/16

    摘要： Organic compounds containing a mercapto group or a dithiane moiety can be transformed into the analogous fluoro or difluoro compounds by reacting them with a halogenating reagent in liquid hydrogen fluoride, optionally containing boron trifluoride or antimony pentafluoride solution, at temperatures from about -80.degree. and 15.degree. C. The method may be descriptively termed "fluorodesulfurization".

    摘要翻译： 含有巯基或二噻吩部分的有机化合物可以通过在约-80°和15°的温度下与任选含有三氟化硼或五氟化锑溶液的液体氟化氢中的卤化试剂反应而转化成类似的氟或二氟化合物 该方法可以被描述性地称为“氟代脱硫”。

    N-chloro-amino acid derivatives activity
    8.
    发明授权
    N-chloro-amino acid derivatives activity 失效

    公开(公告)号：US3966796A

    公开(公告)日：1976-06-29

    申请号：US479560

    申请日：1974-06-14

    申请人： James J. Kaminski ,  Nicolae S. Bodor

    发明人： James J. Kaminski ,  Nicolae S. Bodor

    IPC分类号： C07K5/06 ,  C07C101/10

    CPC分类号： C07K5/06191

    摘要： There is provided, a novel class of compounds exhibiting antibacterial activity, said compounds having the formula: ##EQU1## wherein X and Y each represent a member which may be the same or different selected from the group consisting of H and Cl with the priviso that X and Y cannot represent H simultaneously; R.sub.1 and R.sub.2 each represent a member which may be the same or different selected from the group consisting of an n- or branched alkyl group of from 1 to 20 carbon atoms, an aryl group (phenyl, naphthyl, etc.) and a ##EQU2## (CH.sub.2).sub.n group, wherein n represents an integer of from 2 - 5; and Z represents a member selected from the group consisting of an --OR.sub.3 group, a a ##EQU3## wherein R.sub.4 and R.sub.5 each represent a member which may be the same or different selected from the group consisting of H and an alkyl group of from 1 - 3 carbon atoms, wherein R.sub.6 and R.sub.7 each represent a member which may be the same or different selected from the group consisting of R.sub.1, R.sub.2, or H when X is not Cl or R.sub.1 and R.sub.2 when X is Cl, wherein R.sub.1 and R.sub.2 are defined above, wherein X is as defined above, and wherein R.sub.3 in each case represents a member selected from the group consisting of an n- or branched alkyl group of from 2 - 20 carbon atoms, a --OCH.sub.2 CH.sub.2 (OCH.sub.2 CH.sub.2).sub.n --OR.sub.1 group, wherein R.sub.1 is defined as above and n represents an integer of from 1 - 11, aGroup, wherein W represents a member selected from the group consisting of H, an n- or branched alkyl group of from 1 - 20 carbon atoms, a halogen atom, (Cl, Br, I), an --OR.sub.8 group, and a ##EQU4## group, wherein R.sub.4 and R.sub.5 are as defined above and R.sub.8 represents a member selcted from the group consisting of H and R.sub.1, wherein R.sub.1 is as defined above, and --CH.sub.2 CH.sub.2 --(OCH.sub.2 CH.sub.2).sub.n -- ##SPC1##Group, wherein n represens an integer of from 1 - 20 and R.sub.1 is as defined above,With the further proviso that when X and Y are Cl and R.sub.1 and R.sub.2 are methyl, Z cannot be a member selected from the group consisting of --OCH.sub.3 and NH.sub.2.

    Polyfluoroisoalkoxyalkyl amido carboxylic acids and salts thereof
    9.
    发明授权
    Polyfluoroisoalkoxyalkyl amido carboxylic acids and salts thereof 失效
    聚氟代羟基烷基氨基羧酸及其盐

    公开(公告)号：US3644513A

    公开(公告)日：1972-02-22

    申请号：US3644513D

    申请日：1969-04-23

    申请人： ALLIED CHEM

    发明人： SWEENEY RICHARD F ,  PRICE ALSON K ,  KHAN AZIZ U

    IPC分类号： A62D1/00 ,  C07C235/12 ,  C08K5/20 ,  C07C101/10 ,  C07F1/00

    CPC分类号： A62D1/0014 ,  C07C235/12 ,  C08K5/20

    摘要： POLYFLUOROISOALKOXYALKYL AMIDO CARBOXYLIC ACIDS OF THE FORMULA:

    R1-CF(-R2)-CF(-CF(-R3)-R4)-O-R-CO-N(-R5)-R6-COOH

    WHEREIN R1-R4 ARE EACH INDEPENDENTLY SELECTED FROM THE GROUP CONSISTING OF F, CL, ALKYL AND HALOALKYL GROUPS IN WHICH THE HALOGEN ATOMS ARE CL OR F; R1 AND R4 WHEN TAKEN TOGETHER ARE ALKYLENE OR HALOALKYLENE GROUPS WHICH FORM, WITH THE CARBON CHAIN THEREBETWEEN, A CYCLIC STRUCTURE; R IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF ALKYLENE AND HALOALKYLENE; R5 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND ALKYL, AND R6 IS A MEMBER SELECTED FROM THE GROUP CONSISTING OF ALKYLENE, MONOHYDROXYALKYLENE AND CARBOXYALKYLENE RADICALS; AND SALTS THEREOF CONTAINING A CATION SELECTED FROM THE GROUP CONSISTING OF LI, NA, K, RB, CS, CA, BA, MG, ZN, HG, AL, CR, SN, FE, AG, CU, CO, ZR, PB, MN, OR A RADICAL SELECTED FROM MORPHOLINO, AMMONIUM OR AN ALKYL OR HYDROXYALKYL SUBSTITUTED AMMONIUM RADICAL. PREPARATION BY REACTING CORRESPONDING POLYFLUOROISOALKOXYALKYL AMIDO CARBOXYLIC ACID FLUORIDES OR HALOSULFATES WITH AMINO ACIDS. THE NOVEL COMPOUNDS ARE USEFUL AS EMULSIFYING AGENTS, LEVELING AGENTS, OIL, STAIN AND WATER REPELLENT AGENTS, ADDITIVES TO DRY POWDER FIRE EXTINGUSHING COMPOSITIONS AND AS INTERMEDIATES TO VALUABLE OIL, STAIN AND WATER REPELLENT AGENTS.

    Therapeutic agent
    10.
    发明授权
    Therapeutic agent 失效
    治疗剂

    公开(公告)号：US4501727A

    公开(公告)日：1985-02-26

    申请号：US446721

    申请日：1982-12-03

    申请人： Bernard J. Armitage ,  Margaret L. Donaldson

    发明人： Bernard J. Armitage ,  Margaret L. Donaldson

    IPC分类号： A61K31/13 ,  A61K31/19 ,  A61P25/04 ,  A61P29/00 ,  C07C51/00 ,  C07C57/58 ,  C07C67/00 ,  C07C213/00 ,  C07C215/10 ,  C07C215/40 ,  A61K9/44 ,  C07C101/10

    CPC分类号： C07C57/58

    摘要： The N-methyl-D-glucamine salt of (+)-2-(2-fluoro-4-biphenylyl)propionic acid, which is a novel compound with analgesic, anti-inflammatory and antipyretic properties and which is useful for treating inflammatory conditions including rheumatic disorders and as an analgesic. Pharmaceutical compositions containing the novel salt are also described. Also described are methods for preparing the novel salt by direct salification in an aqueous or non-aqueous medium, for example isopropanol, aqueous tetrahydrofuran, bis(methoxyethyl) ether and 4-methyl-1,3-dioxolan-2-one. Isopropanol is especially preferred.

    摘要翻译： （+） - （ - 2-（2-氟-4-联苯基）丙酸的N-甲基-D-葡糖胺盐，它是具有镇痛，抗炎和解热性能的新型化合物，可用于治疗炎性病症 包括风湿病和止痛药。 还描述了含有新盐的药物组合物。 还描述了通过直接成盐在水性或非水性介质中制备新型盐的方法，例如异丙醇，四氢呋喃水溶液，双（甲氧基乙基）醚和4-甲基-1,3-二氧戊环-2-酮。 异丙醇是特别优选的。