公开(公告)号：US4766222A

公开(公告)日：1988-08-23

申请号：US68748

申请日：1987-06-30

申请人： Claudio Cavazza ,  Paolo De Witt ,  Maria O. Tinti

发明人： Claudio Cavazza ,  Paolo De Witt ,  Maria O. Tinti

IPC分类号： A61K31/215 ,  A61K20060101 ,  A61K31/14 ,  A61K31/195 ,  A61K31/205 ,  A61K31/38 ,  A61P3/06 ,  A61P7/00 ,  A61P9/00 ,  C07C20060101 ,  C07C67/00 ,  C07C227/00 ,  C07C227/16 ,  C07C229/22 ,  C07D333/22 ,  C07D333/24 ,  C07D333/32 ,  C07D333/38 ,  C07D339/02 ,  C07D339/04 ,  C07C101/12

CPC分类号： C07C229/22 ,  A61K9/0019 ,  A61K9/0095 ,  A61K9/12 ,  A61K9/2054 ,  A61K9/2059 ,  C07C2101/08 ,  C07C2101/14 ,  C07C2101/16

摘要： A novel class of acyl-derivatives of carnitine is disclosed wherein the acyl radical is either the radical of unsaturated organic acids (typically, acrylic acid) or the radical of saturated organic acids substituted with tert-alkyl, cycloalkyl, cycloalkenyl, alkoxyl, heterocyclic and carboalkoxylradicals, or with aldehyde or hydroxy groups. These acyl-derivatives of carnitine are useful therapeutical agents in the treatment of cardiac disorders, hyperlipidaemias and hyperlipoproteinaemias.

摘要翻译： 公开了一类新的肉碱酰基衍生物，其中酰基是不饱和有机酸（通常为丙烯酸）或被叔烷基，环烷基，环烯基，烷氧基，杂环取代的饱和有机酸基团 或与醛或羟基相结合。 肉碱的这些酰基衍生物是治疗心脏病，高脂血症和高脂蛋白血症的有用治疗剂。

公开(公告)号：US4544666A

公开(公告)日：1985-10-01

申请号：US487842

申请日：1983-04-22

申请人： Mandayam J. Thirumalachar ,  Mandayam J. Narasimhan ,  Mandayam J. K. Thirumalachar

发明人： Mandayam J. Thirumalachar ,  Mandayam J. Narasimhan ,  Mandayam J. K. Thirumalachar

IPC分类号： A01N33/22 ,  A01N37/02 ,  A01N61/00 ,  C07C53/06 ,  A01N37/10 ,  A61K31/235 ,  A61K31/24 ,  C07C101/12

CPC分类号： C07C53/06 ,  A01N33/22 ,  A01N37/02 ,  A01N61/00

摘要： A chemotherapeutic composition for the control of plant diseases caused by mycoplasma-like organisms, rickettsia-like organisms, or seed-borne legume viruses. The composition is composed essentially of the tannate complex of picro ammonium formate combined with a minor amount of a surfactant sufficient to prevent formation of ammonium picrate. The preparation and use of the composition are disclosed. Also disclosed is a related chemotherapeutic composition for the control of plant diseases caused by plant pathogenic fungi and bacteria and composed essentially of a tannate complex of picro cupric ammonium formate in aqueous solution combined with a minor amount of a surfactant sufficient to prevent formation of ammonium picrate, along with its method of preparation and manner of use.

摘要翻译： 用于控制由支原体样生物，立克次体样生物或种子传播的豆类病毒引起的植物病害的化学治疗组合物。 该组合物基本上由picro的甲酸铵复合物与少量足以防止形成苦味酸铵形成的表面活性剂组合而成。 公开了组合物的制备和用途。 还公开了一种用于控制由植​​物致病真菌和细菌引起的植物疾病的相关化学治疗组合物，并且主要由在水溶液中的微量二甲铵甲酸铵的鞣酸复合物组合，并与少量足以防止形成苦味酸钾的表面活性剂 ，以及其制备方法和使用方法。

公开(公告)号：US4515982A

公开(公告)日：1985-05-07

申请号：US450097

申请日：1982-12-15

申请人： Peter Lechtken ,  Gerhard Mueller ,  Klaus Schmieder

发明人： Peter Lechtken ,  Gerhard Mueller ,  Klaus Schmieder

IPC分类号： C09K15/20 ,  A23L3/34 ,  A23L3/3526 ,  C07C67/00 ,  C07C213/00 ,  C07C225/20 ,  C07C227/00 ,  C07C229/14 ,  C07D265/36 ,  C09K15/30 ,  C07C101/12

CPC分类号： C07D265/36 ,  C09K15/30

摘要： Organic materials which contain from 0.001 to 10% by weight of an aminoreductone I ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are H, methyl or ethyl and R.sup.4 is the radical of a naturally occurring .alpha.- or .beta.-aminoacid or of a C.sub.1 -C.sub.10 -alkyl ester thereof or, in the case of an .alpha.-aminoacid, a lactone having a 2--OH group in the cyclohexenone ring, or R.sup.4 is C.sub.1 -C.sub.20 -alkyl which is unsubstituted or substituted by --OH, C.sub.1 -C.sub.4 -alkoxy or C.sub.1 -C.sub.4 -acyloxy, or is --(CH.sub.2 --CH.sub.2 --O).sub.n H, which may be etherified with a C.sub.1 -C.sub.4 -alkanol or esterified with a C.sub.1 -C.sub.4 -fatty acid, and where n is from 2 to 10, or a mineral salt thereof.Novel compounds Ia differ from I in having the radical R.sup.4a, where R.sup.4a is R.sup.4 with the exception of methyl. Compounds I are prepared by reacting the corresponding 2,3-dihydroxycyclohex-2-en-1-one with an amine HN(R.sup.3)R.sup.4 or a mineral acid salt thereof.

摘要翻译： 含有0.001至10重量％的氨基还原酮I的有机材料，其中R 1，R 2和R 3是H，甲基或乙基，R 4是天然存在的α-或β-氨基酸或C1 -C 10 - 烷基酯，或在α-氨基酸的情况下，在环己烯酮环中具有2-OH基团的内酯，或R4是未被取代或被-OH取代的C1-C20烷基，C1-C4 - 烷氧基或C 1 -C 4 - 酰氧基，或是 - （CH 2 -CH 2 -O）n H，其可以用C 1 -C 4烷醇醚化或用C 1 -C 4脂肪酸酯化，并且其中n为2至 10或其矿物盐。 新颖的化合物Ia与具有自由基R4a的不同之处在于，R4a除了甲基以外是R4a。 化合物I通过使相应的2,3-二羟基环己-2-烯-1-酮与胺HN（R3）R4或其无机酸盐反应来制备。

公开(公告)号：US4259249A

公开(公告)日：1981-03-31

申请号：US048203

申请日：1979-06-13

申请人： Charles R. Degenhardt

发明人： Charles R. Degenhardt

IPC分类号： C09F7/00 ,  C07C101/12

CPC分类号： C07C209/68 ,  C07C227/08

摘要： A method of preparing hydroxyl substituted ammonio carboxylates comprising a single step of reacting an epoxy ester with a tertiary amine in aqueous alcohol, yielding directly said hydroxyl substituted ammonio carboxylates. The hydroxyl substituted ammonio carboxylates are useful as detersive surfactants and as oral anti-ulcer agents.

摘要翻译： 一种制备羟基取代的氨基羧酸盐的方法，其包括将环氧酯与叔胺在含水醇中反应的单步骤，直接得到所述羟基取代的氨基羧酸盐。 羟基取代的氨基羧酸盐可用作去污表面活性剂和口服抗溃疡剂。

公开(公告)号：US3728385A

公开(公告)日：1973-04-17

申请号：US3728385D

申请日：1969-11-28

申请人： COLGATE PALMOLIVE CO

发明人： WIXON H ,  SUNDBY B ,  KENNEY E

IPC分类号： B01J37/00 ,  B01J37/02 ,  B01J37/03 ,  B01J37/18 ,  C07C291/04 ,  C11D1/10 ,  C11D1/88 ,  C11D3/00 ,  C07C101/12

CPC分类号： B01J37/02 ,  B01J37/00 ,  B01J37/03 ,  B01J37/18 ,  C07C291/04 ,  C07C2601/20 ,  C11D1/10 ,  C11D1/88 ,  C11D3/001

摘要： Novel oxides of aminocarboxylates or aminocarboxylic acids are of the formula:

WHEREIN R1 is an aliphatic hydrocarbon radical of four to 20 carbon atoms, R2 is a hydrocarbon radical of one to four carbon atoms or is R3COOX, R3 is a divalent aliphatic or aromatic hydrocarbon radical of one to nine carbon atoms, which may be the same as or different from another R3 radical which may be prsent in the compound, X is hydrogen, alkali metal, alkaline earth metal, other suitable salt-forming metal, ammonium, alkylamine or alkanolamine, which may be the same as or different from any other X in the formula, with it being understood that in the case of divalent or trivalent X''s it may be joined to a plurality of the shown organic moieties through the carboxylic oxygen(s) thereof. The novel compounds are possessed of surface activity and are substantive to fibrous materials, e.g., cotton and wool. They may be used as detergents or components of detergent compositions and serve as softeners for fibrous materials.

摘要翻译： 氨基羧酸盐或氨基羧酸的新型氧化物具有下式：

公开(公告)号：US3689524A

公开(公告)日：1972-09-05

申请号：US3689524D

申请日：1970-05-27

申请人： ALLEN & HANBURYS LTD

发明人： JACK DAVID ,  HARTLEY DAVID ,  LUNTS LAWRENCE HENRY CHARLES

IPC分类号： A61K31/165 ,  A61K31/135 ,  A61K31/24 ,  A61K31/60 ,  A61P9/00 ,  A61P9/08 ,  A61P9/10 ,  A61P9/12 ,  C07C67/00 ,  C07C213/00 ,  C07C215/52 ,  C07C227/00 ,  C07C227/18 ,  C07C229/38 ,  C07C231/00 ,  C07C231/02 ,  C07C237/30 ,  C07C275/24 ,  C07C275/40 ,  C07C301/00 ,  C07C303/40 ,  C07C311/08 ,  C07C101/12 ,  C07C101/42 ,  C07C101/72

CPC分类号： C07C255/00 ,  C07C229/38 ,  C07C275/40

摘要： The present invention provides compounds of the general formula I and physiologically acceptable addition salts thereof: IN WHICH R1 represents a hydrogen atom or a lower alkyl group; R2 represents a hydrogen atom or a benzyl or benzhydryl group; R3 represents a hydrogen atom or a lower alkyl group or R3 represents an arylalkyl or aryloxyalkyl radical, which radicals may optionally be substituted by one or more alkoxy or hydroxyl groups; Z represents a group of formula -(CH2)nY in which n has the value of 0, 1 or 2, and Y represents a hydroxyl radical (except when n has the value O) or an alkoxycarbonyl group of the formula COOR where R represents a hydrogen atom or a lower alkyl group, or Y represents an amido group of formula CONR5R6 in which R5 and R6 are as defined below or a group of formula NR4CONR5R6, or -NR4SO2R7 (in which R4, R5 and R6, which may be the same or different, represent hydrogen atoms or lower alkyl groups and R7 represents a lower alkyl group) except where n O and Y NR4SO2R7, R4 is not hydrogen. Preferably at least one of the groups R1, R2 and R3 is other than hydrogen, particularly when Z represents a -COOR group.

摘要翻译： 本发明提供了通式I的化合物及其生理上可接受的加成盐：

公开(公告)号：US4664852A

公开(公告)日：1987-05-12

申请号：US866144

申请日：1986-05-22

申请人： Paolo Casati ,  Claudio Fuganti

发明人： Paolo Casati ,  Claudio Fuganti

IPC分类号： C07C69/675 ,  C07C20060101 ,  C07C67/00 ,  C07C227/00 ,  C07C227/08 ,  C07C227/18 ,  C07C229/22 ,  C07C231/00 ,  C07C231/04 ,  C07C231/12 ,  C07C235/12 ,  C07C235/80 ,  C07C101/12

CPC分类号： C07C229/22

摘要： A process for preparing L-carnitine (I) wherein(a) diketene (II) is reacted with chlorine, and the chlorination product thus obtained is submitted to amidation by the methylester of an optically-active aminoacid, having formula: ##STR1## wherein R=CH.sub.2 A.sub.r or A.sub.r wherein Ar is a substituted or not-substituted aromatic group, to yield the compound 4-chloro-3-ketobutyrylamide of the methylester of the optically-active aminoacid: (IV)(b) the compound (IV) is reduced in the presence of a reducing agent to yield a mixture (V) of (3R)-4-chloro-3-hydroxybutyrylamide of the methylester of an optically-active acid (VI), and (3S)-4-chloro-3-hydroxybutyrylamide of the methylester of an optically active aminoacid (VII),(c) the compound (VI) is separated and recovered from the reduction reaction product,(d) the compound (VI) is submitted to methanolysis by hydrogen chloride gas in methanol,(e) the methylester of the optically-active aminoacid (III) is precipitated and recovered from the methanolysis reaction product,(f) from the mother liquors the methylester of (3R)-4-chloro-3-hydroxybutyric acid (VIII) is recovered,(g) the compound (VIII) thus obtained is treated with trimethylamine in ethanol, is hydrolyzed with hydrochloric acid and L-carnitine is separated and recovered.

摘要翻译： 一种制备左旋肉碱（I）的方法，其中（a）双烯酮（II）与氯反应，由此获得的氯化产物经过具有下式的光学活性氨基酸的甲酯进行酰胺化： III）其中R = CH 2 Ar或Ar，其中Ar是取代或未取代的芳族基团，得到光学活性氨基酸的甲酯的化合物4-氯-3-酮丁酰胺：（IV）（b）化合物（ IV）在还原剂存在下还原，得到光学活性酸（VI）的甲酯的（3R）-4-氯-3-羟基丁酰胺的混合物（V），和（3S）-4- 光学活性氨基酸（VII）的甲酯的氯-3-羟基丁酰胺，（c）化合物（VI）从还原反应产物中分离回收，（d）化合物（VI）通过氯化氢进行甲醇分解 在甲醇中的气体，（e）光学活性氨基酸（III）的甲酯沉淀并从甲烷中回收 （f）从母液中回收（3R）-4-氯-3-羟基丁酸（VIII）的甲酯，（g）将所得化合物（Ⅷ）用乙醇中的三甲胺处理， 用盐酸水解并分离和回收L-肉碱。

公开(公告)号：US4385926A

公开(公告)日：1983-05-31

申请号：US296597

申请日：1981-08-26

申请人： Francis H. Walker

发明人： Francis H. Walker

IPC分类号： A01N37/46 ,  C07C101/12 ,  A01N9/20

CPC分类号： A01N37/46

摘要： A method of increasing the yield of legumes (soybeans) utilizing a compound of the formula ##STR1## wherein R is selected from the group consisting of --CH.sub.3, --C.sub.2 H.sub.5 and --C.sub.3 H.sub.7.

摘要翻译： 一种利用式“IMAGE”化合物增加豆类（大豆）产量的方法，其中R选自-CH 3，-C 2 H 5和-C 3 H 7。

公开(公告)号：US4018821A

公开(公告)日：1977-04-19

申请号：US616849

申请日：1975-09-25

申请人： Leander Tenud

发明人： Leander Tenud

IPC分类号： C07C229/22 ,  A61K31/13 ,  A61K31/205 ,  C07C20060101 ,  C07C227/12 ,  C07C101/10 ,  C07C101/12

摘要： The process for the production of carnitine hydrochloride which involves placing an ester of .gamma.-halo-acetoacetic acid having the formula: ##STR1## wherein R.sub.1 is hydrogen, R.sub.2 is a lower alkyl group having 1 to 10 carbon atoms and X is a halogen atom selected from the group consisting of chlorine or bromine, in an aqueous solution of excess trimethyl amine held at a temperature between 0.degree. and 50.degree. C., a reaction resulting between said ester and said amine. The excess trimethyl amine is distilled off. The pH of the solution is adjusted between 4 and 8, (3-carbalkoxy-2-oxopropyl)-trimethyl ammonium halide resulting. The (3-carbalkoxy-2-oxopropyl)-trimethyl ammonium is hydrogenated without isolating said halide from solution, a carnitine ester resulting. The carnitine ester is converted by means of aqueous hydrochloric acid into carnitine hydrochloride.

摘要翻译： 生产盐酸左旋肉碱的方法，其中包括将下式所示的γ-卤代乙酰乙酸酯：其中R1为氢，R2为具有1-10个碳原子的低级烷基，X为卤素原子 选自氯或溴，在保持在0℃至50℃之间的过量三甲胺的水溶液中，所述酯与所述胺之间产生反应。 蒸馏除去过量的三甲基胺。 将溶液的pH调节为4至8，得到（3-烷氧基-2-氧代丙基） - 三甲基卤化铵。 氢化（3-碳烷氧基-2-氧代丙基） - 三甲基铵，不从溶液中分离所述卤化物，得到肉碱酯。 肉碱酯通过盐酸水溶液转化为盐酸肉碱。

公开(公告)号：US3868407A

公开(公告)日：1975-02-25

申请号：US41785873

申请日：1973-11-21

申请人： MONSANTO CO

发明人： FRANZ JOHN E ,  NUFER HANS L

IPC分类号： A01N57/20 ,  A01N57/18 ,  A01P13/00 ,  C07F9/38 ,  C07F9/40 ,  C07C101/12

CPC分类号： C07F9/3808

摘要： Carboxyalkyl esters of N-phosphonomethyl glycine and their salts and a process for their preparation are described. These esters and salts are useful as contact herbicides.

摘要翻译： 描述N-膦酰基甲基甘氨酸的羧甲基烷基酯及其盐及其制备方法。 这些酯和盐可用作接触除草剂。