A method of and device for increasing the permeability of the skin of cellsf living beings, according to which the respective cells are introduced in the form of a suspension into an electrically conductive liquid. Thereby there is formed a physiological electrolyte solution which is passed into one of two chambers through a passage of a partition. This partition separates a container into these two chambers, each chamber having an electrode. This passage surrounds the focus of an electric field. The cells in the electrolyte solution are exposed to the electric field while passing from one chamber to the other chamber until macromolecules having a radius of at least 5 A are exchanged through the cell skin between the solution in the interior of the cells and the physiological electrolyte solution.