发明授权
US4089958A 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2]quinoxalin-5(6)-ones and derivatives
thereof
失效
2,3,4,4a-四氢-1H-吡嗪{8 1,2 {9喹喔啉-5（6）酮及其衍生物
- 专利标题： 2,3,4,4A-Tetrahydro-1H-pyrazino[1,2]quinoxalin-5(6)-ones and derivatives thereof
- 专利标题（中）： 2,3,4,4a-四氢-1H-吡嗪{8 1,2 {9喹喔啉-5（6）酮及其衍生物
-
申请号： US752577申请日： 1976-12-20
-
公开(公告)号： US4089958A公开(公告)日： 1978-05-16
- 发明人: Meier E. Freed , John R. Potoski
- 申请人： Meier E. Freed , John R. Potoski
- 申请人地址： NY New York
- 专利权人： American Home Products Corporation
- 当前专利权人： American Home Products Corporation
- 当前专利权人地址： NY New York
- 主分类号： C07C205/12
- IPC分类号： C07C205/12 ; C07D239/42 ; C07D241/04 ; C07D487/04 ; C07F1/00 ; C07F1/08 ; A61K31/495
摘要：
Compounds of the formula ##STR1## WHEREIN R is hydrogen (lower)alkyl, phen(lower)-alkyl, benzoyl(lower)alkyl, or p-halobenzoyl-(lower)alkyl; R.sup.1 is hydrogen or (lower)alkyl; R.sup.2 is hydrogen, (lower)alkyl, (lower)alkoxy, chlorine, fluorine, trifluoromethyl, or amino in the 7-, 8-, or 9-position; R.sup.3 is hydrogen, or (lower)alkyl; and R.sup.4 is hydrogen, (lower)-alkyl, (lower)alkoxy, chlorine, fluorine, or trifluoromethyl in the 7-, 8-, or 9-position; or the non-toxic acid addition salts thereof; exert a hyptotensive effect in hypertensive animals.
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