发明授权
- 专利标题: Bis(2-[(disubstituted amino)methyl]-1H-indole) compounds
- 专利标题(中): 双(2- {8(二取代氨基)甲基{9-1H-吲哚)化合物
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申请号: US861762申请日: 1977-12-19
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公开(公告)号: US4132792A公开(公告)日: 1979-01-02
- 发明人: Harold Zinnes , Neil A. Lindo
- 申请人: Harold Zinnes , Neil A. Lindo
- 申请人地址: NJ Morris Plains
- 专利权人: Warner-Lambert
- 当前专利权人: Warner-Lambert
- 当前专利权人地址: NJ Morris Plains
- 主分类号: C07D209/14
- IPC分类号: C07D209/14 ; C07D209/34 ; C07D487/04 ; A61K31/495 ; C07D403/14
摘要:
Bis(2-[(disubstitutedamino)methyl]-1H-indole) compounds wherein said 2-[(disubstitutedamino)methyl]-1H-indol-3-ylmethylene moieties are linked together through a piperazine or 1,3-dihydro-2H-indol-2-one fragment and acid addition salts thereof which are useful pharmacological agents, especially antifungals, are disclosed. The compounds can be produced by reacting a piperazine or 1,3-dihydro-2H-indole-2-one compound with the appropriate quaternary salt of 2-alkyl-1,2,3,4-tetrahydropyrrolo-[3,4-b]indole.
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