发明授权
- 专利标题: Dicarboxylic acid esters of cardiac glycosides
- 专利标题(中): 强心苷的二羧酸酯
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申请号: US715020申请日: 1976-08-16
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公开(公告)号: US4133949A公开(公告)日: 1979-01-09
- 发明人: Hans-Georg Batz , Hans-Ralf Linke , Klaus Stellner , Gunter Weimann
- 申请人: Hans-Georg Batz , Hans-Ralf Linke , Klaus Stellner , Gunter Weimann
- 申请人地址: DE1 Mannheim-Waldhof
- 专利权人: Boehringer Mannheim GmbH
- 当前专利权人: Boehringer Mannheim GmbH
- 当前专利权人地址: DE1 Mannheim-Waldhof
- 优先权: DEX2537129 19750820
- 主分类号: C07D249/20
- IPC分类号: C07D249/20 ; A61K31/22 ; A61K31/265 ; A61K31/275 ; A61K31/40 ; A61K31/44 ; A61K31/445 ; A61K31/70 ; A61P43/00 ; C07C43/32 ; C07C67/00 ; C07C69/34 ; C07C69/42 ; C07C69/67 ; C07C205/43 ; C07C253/00 ; C07C255/16 ; C07C327/22 ; C07D207/40 ; C07D207/46 ; C07D209/48 ; C07D213/63 ; C07D227/12 ; C07D249/18 ; C07J19/00 ; C07J41/00 ; C07J43/00 ; C07K19/00 ; G01N33/53 ; G01N33/531
摘要:
New reactive asymmetrical dicarboxylic acid ester compounds of the formula ##STR1## wherein R.sub.1 is an alkyl radical containing up to 3 carbon atoms or is a digoxin or digitoxin residue, R.sub.2 and R.sub.3, which may be the same or different, are alkoxy radicals containing up to 3 carbon atoms or together represent an oxygen atom, X is a cyanomethoxy, succinimide-N-oxy, N-methyl-pyridiniumoxy, 2,4-dinitrophenoxy, 2,4,5-trichlorophenoxy, pentachlorophenoxy, phenylthio, p-nitrophenoxy, p-nitrophenylthio, piperidyl-N-oxy, phthalimido-N-oxy or benztriazol-N-oxy radical and n is 2, 3, 4 or 5. are useful for the preparation of reagents for the investigation of cardiac glycosides (Digitalis glycosides).