发明授权
- 专利标题： Isocoformycin and a process for the production thereof
- 专利标题（中）： 异青霉素及其制备方法
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申请号： US858928申请日： 1977-12-09
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公开(公告)号： US4163839A公开(公告)日： 1979-08-07
- 发明人: Hamao Umezawa , Tomio Takeuchi , Shinichi Kondo , Masami Shimazaki
- 申请人： Hamao Umezawa , Tomio Takeuchi , Shinichi Kondo , Masami Shimazaki
- 申请人地址： JPX Tokyo
- 专利权人： Zaidan Hojin Biselbutsu Kagaku Kenkyu Kai
- 当前专利权人： Zaidan Hojin Biselbutsu Kagaku Kenkyu Kai
- 当前专利权人地址： JPX Tokyo
- 主分类号： C07H19/052
- IPC分类号： C07H19/052 ; C07H19/16 ; C07H19/04 ; A61K31/70
摘要：
A novel, unique nucleoside, 3-.beta.-D-ribofuranosyl-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-7-ol, named isocoformycin, of the formula ##STR1## is provided by ring expansion of derivatives of 9-.beta.-D-ribofuranosyl-6-hydroxymethyl-1,6-dihydropurine. Isocoformycin markedly inhibits deaminating enzymes which inactivate formycin and adenine arabinoside (also known as ara-A and Vidarabine). Formycin and adenine arabinoside are used as antiviral and antitumor agents in mammals and birds and isocoformycin is advantageous to prolong the activity and effect of formycin and adenine arabinoside.
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