发明授权
US4188480A Process for the production of a 9,3"-di-acyl derivative of a macrolide
antibiotic
失效
用于生产大环内酯类抗生素的9,3“ - 二 - 酰基衍生物的方法
- 专利标题： Process for the production of a 9,3"-di-acyl derivative of a macrolide antibiotic
- 专利标题（中）： 用于生产大环内酯类抗生素的9,3“ - 二 - 酰基衍生物的方法
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申请号： US933188申请日： 1978-08-10
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公开(公告)号： US4188480A公开(公告)日： 1980-02-12
- 发明人: Takeshi Nakamura , Satoru Nakabayashi , Shunzo Fukatsu , Shigeo Seki
- 申请人： Takeshi Nakamura , Satoru Nakabayashi , Shunzo Fukatsu , Shigeo Seki
- 申请人地址： JPX Tokyo
- 专利权人： Meiji Seika Kaisha, Ltd.
- 当前专利权人： Meiji Seika Kaisha, Ltd.
- 当前专利权人地址： JPX Tokyo
- 优先权： JPX52-97071 19770815
- 主分类号： A61K31/70
- IPC分类号： A61K31/70 ; A61K31/7042 ; A61K31/7048 ; A61P31/04 ; C07H17/08 ; C07H1/00
摘要：
A 9,3"-di-acyl derivative of a macrolide antibiotic can be readily produced by reacting a macrolide antibiotic or an acyl derivative thereof with an organic acid halide, particularly an alkanoic acid halide, in a solvent and in the presence of a molecular sieve consisting of a synthetic zeolite and then de-acylating partially the resultant acylation products by a partial hydrolysis in an aqueous alcohol to give the 9,3"-di-acyl derivative of the macrolide antibiotic.
公开/授权文献
- US6022833A Multicomponent mixtures for use in geological exploration 公开/授权日：2000-02-08
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