发明授权
- 专利标题: Peptides related to somatostatin
- 专利标题(中): 与生长抑素有关的肽
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申请号: US948117申请日: 1978-10-02
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公开(公告)号: US4202802A公开(公告)日: 1980-05-13
- 发明人: James E. Shields
- 申请人: James E. Shields
- 申请人地址: IN Indianapolis
- 专利权人: Eli Lilly and Company
- 当前专利权人: Eli Lilly and Company
- 当前专利权人地址: IN Indianapolis
- 主分类号: A61K38/04
- IPC分类号: A61K38/04 ; A61P3/00 ; A61P3/08 ; A61P3/10 ; C07C231/00 ; C07K1/113 ; C07K14/575 ; C07K14/655 ; C08L89/00 ; A61K37/00 ; C07C103/52
摘要:
The tetradecapeptides of the formula ##STR1## wherein X is H--Ala--D--Ala, H--D--Ala--Gly, or H--D--Val--Gly; and X is Ala--Leu, Ala--Phe, Ala--D--Phe, D--Ala--Phe, or D--Ala--Cha; or the non-toxic, pharmaceutically acceptable acid addition salts thereof; inhibit secretion of growth hormone, while not materially inhibiting the secretion of insulin or glucagon. Intermediates used in the synthesis of the tetradecapeptides are also described.
公开/授权文献
- US4700987A Folding table mechanism 公开/授权日:1987-10-20
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