发明授权
- 专利标题: New prostaglandin-like diketals
- 专利标题(中): 新的前列腺素样二缩酮
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申请号: US855591申请日: 1977-11-29
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公开(公告)号: US4209444A公开(公告)日: 1980-06-24
- 发明人: Manfred Baumgarth , Dieter Orth , Hans-Eckart Radunz , Reinhard Lissner , Jurgen Maisenbacher
- 申请人: Manfred Baumgarth , Dieter Orth , Hans-Eckart Radunz , Reinhard Lissner , Jurgen Maisenbacher
- 申请人地址: DEX Darmstadt
- 专利权人: Merck Patent Gesellschaft mit beschrankter Haftung
- 当前专利权人: Merck Patent Gesellschaft mit beschrankter Haftung
- 当前专利权人地址: DEX Darmstadt
- 优先权: DEX2654113 19761129
- 主分类号: A61K31/20
- IPC分类号: A61K31/20 ; A61K31/215 ; A61P43/00 ; C07C67/00 ; C07C401/00 ; C07C405/00 ; C07D317/72 ; C07D319/08 ; C07C177/00
摘要:
Compounds of formula ##STR1## their mirror images and racemic mixtures, and the physiologically acceptable salts thereof,wherein A and D each are ketalized carbonyl groups; B is --CH.sub.2 --, --CH(CH.sub.3)--, --C(CH.sub.3).sub.2 --, --CH.sub.2 CH.sub.2 --, --CH(CH.sub.3)CH.sub.2 ----C(CH.sub.3).sub.2 CH.sub.2 -- or --CH.sub.2 O--; R.sup.1 is H or alkyl of 1-4 C-atoms; and R.sup.2 is alkyl of 3 to 5 C-atoms, phenyl or phenyl substituted one to three times by F, Cl, CF.sub.3, OH, OCH.sub.3, OC.sub.2 H.sub.5 or alkyl of 1 to 3 C-atoms inhibit aggregation and/or adhesion of thrombocytes.