发明授权
- 专利标题: Aminoalkyl-substituted benzimidazolidin-2-ones
- 专利标题(中): 氨基烷基取代的苯并咪唑烷-2-酮
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申请号: US26608申请日: 1979-04-03
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公开(公告)号: US4215119A公开(公告)日: 1980-07-29
- 发明人: Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Richard Reichl , Werner Traunecker , Wolfgang Hoefke
- 申请人: Anton Mentrup , Kurt Schromm , Ernst-Otto Renth , Richard Reichl , Werner Traunecker , Wolfgang Hoefke
- 申请人地址: DEX Ingelheim am Rhein
- 专利权人: Boehringer Ingelheim GmbH
- 当前专利权人: Boehringer Ingelheim GmbH
- 当前专利权人地址: DEX Ingelheim am Rhein
- 优先权: DEX2609645 19760309
- 主分类号: C07D215/02
- IPC分类号: C07D215/02 ; A61K31/404 ; A61K31/415 ; A61K31/4166 ; A61K31/4184 ; A61K31/42 ; A61K31/423 ; A61K31/4245 ; A61K31/536 ; A61P9/08 ; A61P9/12 ; A61P11/00 ; A61P25/24 ; A61P25/26 ; C07D215/22 ; C07D215/227 ; C07D223/04 ; C07D233/32 ; C07D233/36 ; C07D235/04 ; C07D235/22 ; C07D235/26 ; C07D263/54 ; C07D263/58 ; C07D265/22 ; C07D265/36 ; C07D405/04 ; C07D405/12 ; C07D413/12 ; A61K31/535
摘要:
Racemic and optically active compounds of the formulaQ-C.sub.n H.sub.2n -NH-Rwherein Q is ##STR1## where R.sub.1 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, trifluoromethyl or amino,R.sub.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or trifluoromethyl,R.sub.1 and R.sub.2, together with each other, are methylenedioxy or ethylenedioxy, andA is --O--, --CH.sub.2 --CH.sub.2 --, or --NR.sub.3 -- where R.sub.3 is hydrogen or alkyl or 1 to 4 carbon atoms,n is an integer from 2 to 6, inclusive, andR is hydrogen, benzyl or ##STR2## where R.sub.4 is hydrogen, methyl or ethyl,R.sub.5, R.sub.6 and R.sub.7, which may be identical to or different from each other, are each hydrogen, halogen, hydroxymethyl, trifluoromethyl, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, nitro, cyano, --CONHR.sub.3, --CONHOH, --COOR.sub.3, R.sub.8 O--, methylsulfonylmethyl or, when one or two of R.sub.5 through R.sub.7 are other than halogen or trifluoromethyl, also --NR.sub.3 R.sub.9,whereR.sub.3 has the meanings defined above,R.sub.8 is hydrogen, alkanoyl of 1 to 20 carbon atoms, alkyl of 1 to 4 carbon atoms, or aralkyl, andR.sub.9 is hydrogen, lower alkanoyl, methanesulfonyl, carbamoyl, dimethylsulfamoyl, or alkoxycarbonyl of 2 to 5 carbon atoms, andR.sub.5 and R.sub.6, together with each other, are --O--CH.sub.2 --O, --O--CH.sub.2 --CH.sub.2 --O--, --CH.dbd.CH--CH.dbd.CH--, --O--CH.sub.2 --CONH--, --CH.sub.2 --CH.sub.2 --COHN-- or --O--CO--NH--,and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as vasodilators and CNS-stimulators.