发明授权
- 专利标题： Synthesis of .beta.-lactams having a substituted hydroxymethylene group at the position .alpha. to the lactam carbonyl group
- 专利标题（中）： 在内酰胺羰基的α位具有取代羟基亚甲基的β-内酰胺的合成
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申请号： US81734申请日： 1979-10-04
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公开(公告)号： US4283531A公开(公告)日： 1981-08-11
- 发明人: Ashit K. Ganguly , Viyyoor M. Girijavallabhan , Patricia Cavender , Olga Sarre , Stuart W. McCombie
- 申请人： Ashit K. Ganguly , Viyyoor M. Girijavallabhan , Patricia Cavender , Olga Sarre , Stuart W. McCombie
- 申请人地址： NJ Kenilworth
- 专利权人： Schering Corporation
- 当前专利权人： Schering Corporation
- 当前专利权人地址： NJ Kenilworth
- 主分类号： C07D463/00
- IPC分类号： C07D463/00 ; C07D477/02 ; C07D477/10 ; C07D487/04 ; C07D499/00 ; C07D503/00 ; C07D505/00 ; C07D501/00
摘要：
.beta.-Lactams having a substituted hydroxymethylene group at the position .alpha. to the lactam carbonyl group are prepared by reaction of an .alpha.-halo-.beta.-lactam with zinc or zinc amalgam in an anhydrous aprotic medium to produce an intermediate which in situ reacts with an appropriate aldehyde or ketone.Also described are novel penicillins and cephalosporins having useful antibacterial activity.
公开/授权文献
- USD415616S Broom block 公开/授权日：1999-10-26
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