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    Aminoeverninomicin and derivatives thereof
    5.
    发明授权
    Aminoeverninomicin and derivatives thereof 失效
    氨基炔诺胺及其衍生物

    公开(公告)号：US4129720A

    公开(公告)日：1978-12-12

    申请号：US833838

    申请日：1977-09-16

    申请人： Ashit K. Ganguly ,  Viyyoor M. Girijavallabhan ,  Olga Sarre ,  Hans Reimann

    发明人： Ashit K. Ganguly ,  Viyyoor M. Girijavallabhan ,  Olga Sarre ,  Hans Reimann

    IPC分类号： C07H13/08 ,  A61K31/70 ,  A61K31/7024 ,  A61P31/04 ,  C07H19/01 ,  C07H17/04

    CPC分类号： C07H19/01

    摘要： Everninomicin B, C or D may be converted to amino derivatives by reductive means. The amino derivatives may, subsequently, be converted to novel N-acyl, N-alkyl or N,N-dialkyl derivatives. Alternatively, everninomicins B, C or D may be converted to N-acyl-N-hydroxylamino derivatives also by reductive means. The derivatives so-produced and the non-toxic pharmaceutically acceptable cationic salts thereof are novel and are antibacterial agents.

    摘要翻译： Everninomicin B，C或D可以通过还原方法转化为氨基衍生物。 随后将氨基衍生物转化为新的N-酰基，N-烷基或N，N-二烷基衍生物。 或者，也可以通过还原方法将乙酰丙酮蛋白B，C或D转化为N-酰基-N-羟基氨基衍生物。 所产生的衍生物及其无毒的药学上可接受的阳离子盐是新颖的，并且是抗菌剂。

    Preparation of 12,13-desepoxy-12,13-dehydrorosamicin
    7.
    发明授权
    Preparation of 12,13-desepoxy-12,13-dehydrorosamicin 失效
    12,13-去环氧-12,13-脱氢谷氨酰胺的制备

    公开(公告)号：US3975372A

    公开(公告)日：1976-08-17

    申请号：US554266

    申请日：1975-02-28

    申请人： Ashit K. Ganguly ,  Olga Sarre

    发明人： Ashit K. Ganguly ,  Olga Sarre

    IPC分类号： C07H17/08

    CPC分类号： C07H17/08

    摘要： Described is a novel process for the preparation of 12,13-desepoxy-12,13-dehydrorosamicin by reducing rosamicin in a mineral acid solution containing Cr.sup.+.sup.+ cations. Rosamicin is an antibiotic elaborated by Micromonospora rosaria.

    摘要翻译： 描述了通过还原含有Cr ++阳离子的无机酸溶液中的罗斯玛汀来制备12,13-去环氧基-12,13-脱氢谷氨酰胺的新方法。 罗素霉素是由小单孢菌（Rosomonica）所制造的抗生素。

    Method of using reduction products of everninomicins as antibacterial agents and pharmaceutical compositions useful therefor
    10.
    发明授权
    Method of using reduction products of everninomicins as antibacterial agents and pharmaceutical compositions useful therefor 失效
    使用everninomicins的还原产物作为抗菌剂的方法和用于其的药物组合物

    公开(公告)号：US4006225A

    公开(公告)日：1977-02-01

    申请号：US570117

    申请日：1975-04-21

    申请人： Ashit K. Ganguly ,  Olga Sarre

    发明人： Ashit K. Ganguly ,  Olga Sarre

    IPC分类号： C07H19/01 ,  A61K31/70

    CPC分类号： C07H19/01

    摘要： Everninomicin antibiotics having a nitro function, e.g. everninomicin B, everninomicin C, and everninomicin D, upon treatment with aluminum amalgam in aqueous alkanol are converted to a mixture of at least two reduction products having antibacterial activity, said reduction products being an everninomicin having a nitroso function and an everninomicin having a hydroxylamino function. The nitrosoeverninomicins are also prepared by treating the corresponding hydroxylaminoeverninomicin with an oxidizing reagent selected from the group consisting of aerial oxidation in alkaline solution, and an alkali metal hypobromite in an aprotic solvent. The everninomicin reduction products and salts thereof are described as well as nitrone derivatives of the hydroxylaminoeverninomicins and salts thereof, all of which possess antibacterial activity. A preferred compound is hydroxylaminoeverninomicin D, particularly the sodium salt thereof.

    摘要翻译： 具有硝基功能的Everninomicin抗生素，例如 everninomicin B，everninomicin C和everninomicin D在铝链烷醇水溶液处理后，转化为具有抗菌活性的至少两种还原产物的混合物，所述还原产物是具有亚硝基功能的乙酰氨基葡蛋白酶和具有羟基氨基官能团的依托米酮 。 还可以通过用选自碱性溶液中的空气氧化的氧化剂和非质子溶剂中的碱金属次溴酸盐处理相应的羟基氨基炔诺酮来制备亚硝基诺霉素。 还描述了依维生素A还原产物及其盐以及羟基氨基炔诺酮及其盐的硝酮衍生物，它们都具有抗菌活性。 优选的化合物是D-氨基甘氨酸，尤其是其钠盐。