发明授权
US4296117A 1-Aryloxy-2-hydroxy-3-[(Benzimidazolinone-substituted
alkyl)-amino]propanes and salts thereof
失效
1-芳氧基-2-羟基-3 - [（苯并咪唑啉酮取代的烷基） - 氨基]丙烷及其盐
- 专利标题： 1-Aryloxy-2-hydroxy-3-[(Benzimidazolinone-substituted alkyl)-amino]propanes and salts thereof
- 专利标题（中）： 1-芳氧基-2-羟基-3 - [（苯并咪唑啉酮取代的烷基） - 氨基]丙烷及其盐
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申请号： US112640申请日： 1980-01-16
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公开(公告)号： US4296117A公开(公告)日： 1981-10-20
- 发明人: Herbert Koppe , Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Wolfgang Hoefke , Gojko Muacevic
- 申请人： Herbert Koppe , Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Wolfgang Hoefke , Gojko Muacevic
- 申请人地址： DEX Ingelheim am Rhein
- 专利权人： Boehringer Ingelheim GmbH
- 当前专利权人： Boehringer Ingelheim GmbH
- 当前专利权人地址： DEX Ingelheim am Rhein
- 优先权： DEX2644833 19761005
- 主分类号： C07D233/36
- IPC分类号： C07D233/36 ; A61K31/415 ; A61K31/4166 ; A61K31/4184 ; A61K31/435 ; A61K31/47 ; A61K31/495 ; A61K31/496 ; A61K31/535 ; A61K31/5355 ; A61K31/5375 ; A61K31/538 ; A61P9/00 ; A61P25/24 ; A61P25/26 ; C07D205/04 ; C07D209/34 ; C07D215/22 ; C07D215/227 ; C07D233/32 ; C07D235/26 ; C07D265/18 ; C07D265/28 ; C07D265/30
摘要：
Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen or substituents of various types;R.sub.4 is hydrogen; alkyl of 1 to 5 carbon atoms; or optionally substituted aralkyl of 7 to 14 carbon atoms;R.sub.5 is a heterocycle;D is alkylene of 1 to 12 carbon atoms; andA is hydrogen or acyl;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as .alpha.- and .beta.-adrenergic receptor blocking agents and antidepressants.
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