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    N-[1-(4-Amino-6,7-dialkoxy-2-quinazolinyl)-4-piperidy l]-oxazolidine-2,4-diones
    9.
    发明授权
    N-[1-(4-Amino-6,7-dialkoxy-2-quinazolinyl)-4-piperidy l]-oxazolidine-2,4-diones 失效
    N- [1-（4-氨基-6,7-二烷氧基-2-喹唑啉基）-4-哌啶基] - 恶唑烷-2,4-二酮

    公开(公告)号：US4539323A

    公开(公告)日：1985-09-03

    申请号：US531842

    申请日：1983-09-14

    申请人： Anton Mentrup ,  Ernst-Otto Renth ,  Kurt Schromm ,  Wolfgang Hoefke ,  Wolfram Gaida

    发明人： Anton Mentrup ,  Ernst-Otto Renth ,  Kurt Schromm ,  Wolfgang Hoefke ,  Wolfram Gaida

    IPC分类号： C07D239/95 ,  A61K31/505 ,  A61K31/517 ,  A61P9/08 ,  A61P9/12 ,  A61P25/02 ,  C07D263/44 ,  C07D401/14 ,  C07D413/04 ,  C07D413/14 ,  C07D491/056

    CPC分类号： C07D413/04 ,  C07D413/14

    摘要： Compounds of the formula ##STR1## wherein R.sub.1 and R.sub.2, which may be identical to or different from each other, are each independently hydrogen, straight or branched alkyl of 1 to 8 carbon atoms or arylmethyl; orR.sub.1 and R.sub.2, together with each other, are --(CH.sub.2).sub.4 or --(CH.sub.2).sub.5 --; andR.sub.3 and R.sub.4, which may be identical to or different from each other, are each independently hydrogen, straight or branched alkyl of 1 to 4 carbon atoms or arylmethyl; orR.sub.3 and R.sub.4, together with each other, are --CH.sub.3 -- or --CH.sub.2 --CH.sub.2 --;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful for the treatment of cardiovascular diseases, especially hypertension.

    摘要翻译： 其中R 1和R 2可以相同或不同，各自独立地为氢，1至8个碳原子的直链或支链烷基或芳基甲基; 或R 1和R 2彼此一起为 - （CH 2）4或 - （CH 2）5 - ; 并且可以相同或不同的R 3和R 4各自独立地为氢，1至4个碳原子的直链或支链烷基或芳基甲基; 或R 3和R 4彼此一起为-CH 3 - 或-CH 2 -CH 2 - ; 和无毒的，药学上可接受的酸加成盐。 化合物及其盐可用于治疗心血管疾病，特别是高血压。

    3,1 Benzoxazin-2-ones and use thereof
    10.
    发明授权
    3,1 Benzoxazin-2-ones and use thereof 失效
    3，苯并恶嗪-2-酮及其用途

    公开(公告)号：US4341778A

    公开(公告)日：1982-07-27

    申请号：US280349

    申请日：1981-07-06

    申请人： Anton Mentrup ,  Kurt Schromm ,  Ernst-Otto Renth ,  Wolfgang Hoefke ,  Wolfram Gaida ,  Ilse Streller ,  Armin Fugner

    发明人： Anton Mentrup ,  Kurt Schromm ,  Ernst-Otto Renth ,  Wolfgang Hoefke ,  Wolfram Gaida ,  Ilse Streller ,  Armin Fugner

    IPC分类号： C07D265/16 ,  A61K31/535 ,  A61K31/536 ,  A61P9/00 ,  A61P9/08 ,  A61P9/12 ,  A61P11/08 ,  A61P13/02 ,  A61P15/00 ,  C07D265/18 ,  C07D265/22

    CPC分类号： C07D265/18

    摘要： The invention relates to compounds of general formula I ##STR1## (wherein R.sub.1 and R.sub.2, which may be the same or different, each represents a hydrogen atom or a (C.sub.1 -C.sub.4) alkyl group;R.sub.3 and R.sub.4, which may be the same or different, each represents a hydrogen, fluorine or chlorine atom or a hydroxy, methyl, ethyl or (C.sub.1 -C.sub.4) alkoxy group, or R.sub.3 together with R.sub.4 represents a methylenedioxy group;R.sub.5 and R.sub.6, which may be the same or different, each represents a hydrogen atom or a methyl group;R.sub.7 represents a group of formula ##STR2## R represents a hydrogen atom or a (C.sub.1 -C.sub.4) alkyl group; R.sub.8 represents a fluorine or chlorine atom or a (C.sub.1 -C.sub.4) alkyl, (C.sub.1 -C.sub.4) alkylthio, hydroxymethyl, CONHR.sub.11, SO.sub.2 NHR.sub.11, OR.sub.12, methoxycarbonyl, ethoxycarbonyl or NHSO.sub.2 CH.sub.3 group;R.sub.9 represents a hydrogen, fluorine or chlorine atom or a OR.sub.12 group;R.sub.10 represents a hydrogen or chlorine atom or an amino, methyl or methoxy group;R.sub.11 represents a hydrogen atom or a methyl, ethyl or hydroxyethyl group;R.sub.12 represents a hydrogen atom or a (C.sub.1 -C.sub.4) alkyl, (C.sub.1 -C.sub.4) alkyl-CO, aryl-CH.sub.2 or aryl-CO group; andn represents 1, 2 or 3) and acid addition salts thereof as well as to processes for their preparation and pharmaceutical compositions containing them. The compounds of the invention possess interesting pharmacological properties in particular displaying hypotensive and selective tocolytic effects.

    摘要翻译： 本发明涉及通式I（I）的化合物（其中R 1和R 2可以相同或不同，各自表示氢原子或（C 1 -C 4）烷基; R 3和R 4可以 相同或不同，各自表示氢，氟或氯原子或羟基，甲基，乙基或（C1-C4）烷氧基，或R3与R4一起代表亚甲二氧基; R5和R6可以相同 或不同的，各自表示氢原子或甲基; R 7表示下式的基团：R表示氢原子或（C 1 -C 4）烷基; R 8表示氟或氯原子或（C 1 -C 4） ）烷基，（C1-C4）烷硫基，羟甲基，CONHR11，SO2NHR11，OR12，甲氧基羰基，乙氧基羰基或NHSO2CH3基; R9表示氢，氟或氯原子或OR12基团; R10表示氢或氯原子或氨基， 甲基或甲氧基; R11表示氢原子或甲基，乙基或羟乙基; R12表示a 氢原子或（C 1 -C 4）烷基，（C 1 -C 4）烷基-CO，芳基-CH 2或芳基-CO基团; 和n表示1,2或3）及其酸加成盐以及其制备方法和含有它们的药物组合物。 本发明的化合物具有特别显示降血压和选择性溶瘤作用的有趣的药理学性质。