发明授权
- 专利标题： Tripeptides acting on the central nervous system and a process for the preparation thereof
- 专利标题（中）： 作用于中枢神经系统的三肽及其制备方法
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申请号： US163829申请日： 1980-06-27
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公开(公告)号： US4299821A公开(公告)日： 1981-11-10
- 发明人: Lajos Kisfaludy , Tamas Szirtes , Lajos Balaspiri , Eva Palosi , Laszlo Szporny , Adam Sarkadi
- 申请人： Lajos Kisfaludy , Tamas Szirtes , Lajos Balaspiri , Eva Palosi , Laszlo Szporny , Adam Sarkadi
- 申请人地址： HUX Budapest
- 专利权人： Richter Gedeon Vegyeszeti Gyar Rt.
- 当前专利权人： Richter Gedeon Vegyeszeti Gyar Rt.
- 当前专利权人地址： HUX Budapest
- 优先权： HUXRI717 19790628
- 主分类号： C07K5/08
- IPC分类号： C07K5/08 ; A61K38/04 ; A61K38/06 ; A61P25/00 ; C07K1/113 ; C07K5/062 ; C07K5/097 ; C07K14/575 ; A61K37/00 ; C07C103/52
摘要：
The invention relates to new peptide derivatives which act on the central nervous system and correspond to the general formula (I),Glp--X--Y--NH--A (I)whereinX is L-norleucyl, L-leucyl, L-norvalyl, D-leucyl, L-prolyl, L-2-aminobutyryl, L-valyl, L-threonyl, L-isoleucyl, L-2-aminodecanoyl, L-cyclohexylalanyl or L-tert.-butyl-seryl group andY is L-prolyl group, orX is L-histidyl group andY is L-homoprolyl or D-pipecolyl group, furthermoreA is hydrogen, a C.sub.1-10 alkyl group or a C.sub.1-3 alkyl group having a dimethylamino substituent,with the proviso that if X is L-leucyl group, A is other than hydrogen, and pharmaceutically acceptable complexes thereof.These compounds are prepared by methods commonly applied in the peptide chemistry.
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