发明授权
US4379164A Vasodilative 4-thia-PGI.sub.1 and 4-sulfinyl-PGI.sub.1 and derivatives
thereof
失效
血管扩张型4-thia-PGI1和4-亚磺酰基-PGI1及其衍生物
- 专利标题： Vasodilative 4-thia-PGI.sub.1 and 4-sulfinyl-PGI.sub.1 and derivatives thereof
- 专利标题（中）： 血管扩张型4-thia-PGI1和4-亚磺酰基-PGI1及其衍生物
-
申请号： US314433申请日： 1981-10-23
-
公开(公告)号： US4379164A公开(公告)日： 1983-04-05
- 发明人: Istvan Tomoskozi , Peter Gyory , Gabor Kovacs , Sandor Virag , Peter Kormoczy , Istvan Stadler
- 申请人： Istvan Tomoskozi , Peter Gyory , Gabor Kovacs , Sandor Virag , Peter Kormoczy , Istvan Stadler
- 申请人地址： HUX Budapest
- 专利权人： Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.
- 当前专利权人： Chinoin Gyogyszer es Vegyeszeti Termekek Gyara R.T.
- 当前专利权人地址： HUX Budapest
- 优先权： HUX2596 19801028
- 主分类号： C07D307/935
- IPC分类号： C07D307/935 ; A61K31/557 ; A61K31/5575 ; A61P1/04 ; A61P9/08 ; A61P11/08 ; C07C405/00 ; C07D307/937 ; A61K31/335
摘要：
A compound having vasodilative, bronchodilative, stomach-mucosa-protective and platelet-aggregation-inhibiting activity has the formulaA 4-thia- or 4-sulfinyl-PGI.sub.1 -compound of the formula I ##STR1## wherein Q stands for --S-- or --SO--,A stands for C.sub.1-6 straight or branched chain alkylene,B stands for ethylene, vinylene or ethinylene,R.sup.1 represents hydrogen or C.sub.1-4 alkyl,R.sup.2 represents C.sub.1-8 straight or branched chain alkyl or mono-substituted aryl-oxy-methyl,R.sup.3 stands for hydrogen or acetyl, andZ represents --COOH, --CN, --CH.sub.2 OH or --COOW, wherein W stands for an equivalent of a pharmacologically acceptable cation or C.sub.1-4 alkyl.