发明授权
US4391995A 4-Phenoxy-phenoxy-alkane-carboxylic acid derivatives and process for
their manufacture
失效
4-苯氧基 - 苯氧基 - 烷烃 - 羧酸衍生物及其制备方法
- 专利标题: 4-Phenoxy-phenoxy-alkane-carboxylic acid derivatives and process for their manufacture
- 专利标题(中): 4-苯氧基 - 苯氧基 - 烷烃 - 羧酸衍生物及其制备方法
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申请号: US265902申请日: 1981-05-21
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公开(公告)号: US4391995A公开(公告)日: 1983-07-05
- 发明人: Helmut Nahm , Ernold Granzer
- 申请人: Helmut Nahm , Ernold Granzer
- 申请人地址: DEX Frankfurt am Main
- 专利权人: Hoechst Aktiengesellschaft
- 当前专利权人: Hoechst Aktiengesellschaft
- 当前专利权人地址: DEX Frankfurt am Main
- 优先权: DEX2136828 19710723
- 主分类号: A61K31/19
- IPC分类号: A61K31/19 ; C07C37/05 ; C07C43/263 ; C07C43/29 ; C07C51/09 ; C07C59/68 ; C07C59/70 ; C07C69/712 ; C07C2/88
摘要:
Novel 4-phenoxy-phenoxy-alkane-carboxylic acid derivatives of the formula I ##STR1## in which R.sub.1 stands for hydrogen, methylithio, cyclopentyl, cyclohexyl, phenyl, methylcycylohexyl, ethylcyclohexyl, or R.sub.1 and R.sub.3 together stand for a --CH.dbd.CH--CH.dbd.CH-- bridge or--unless at least one of the substituents R.sub.2 to R.sub.8 stands for hydrogen, or if R.sub.9 stands for a radical having at least 2 carbon atoms--for chlorine,R.sub.2 and R.sub.3, independent of one another, each stands for hydrogen, chlorine or alkyl of 1 to 4 carbon atoms,R.sub.4 stands for hydrogen, chlorine, alkyl of 1 to 4 carbon atoms, cyclopentyl, cyclohexyl, methylcyclohexyl or R.sub.3 and R.sub.4 together stand for a --CH.dbd.CH--CH.dbd.CH-- bridge,R.sub.5, R.sub.6 and R.sub.7, independent of one another, each stands for hydrogen or alkyl of 1 to 4 carbon atoms,R.sub.8 stands for hydrogen, alkyl of 1 to 4 carbon atoms or allyl,R.sub.9 stands for alkyl of 1 to 10 carbon atoms or phenyl andX stands for hydrogen, the cation of a physiologically acceptable inorganic or organic base of a hydrocarbon radical of 1 to 10 carbon atoms, having a strong action on the lipide and cholesterine metabolism and a process for this manufacture.