公开(公告)号：US4238626A

公开(公告)日：1980-12-09

申请号：US905049

申请日：1978-05-11

申请人： Helmut Nahm ,  Ernold Granzer

发明人： Helmut Nahm ,  Ernold Granzer

IPC分类号： A61K31/19 ,  C07C37/05 ,  C07C43/263 ,  C07C43/29 ,  C07C51/09 ,  C07C59/68 ,  C07C59/70 ,  C07C69/712 ,  C07C69/736

CPC分类号： C07C323/00 ,  C07C51/09 ,  C07C59/68

摘要： Novel 4-phenoxy-phenoxy-alkane-carboxylic acid derivatives of the formula I ##STR1## in which R.sub.1 stands for hydrogen, methylthio, cyclopentyl, cyclohexyl, phenyl, methylcyclohexyl, ethylcyclohexyl, or R.sub.1 and R.sub.3 together stand for a --CH.dbd.CH--CH.dbd.CH-- bridge or--unless at least one of the substituents R.sub.2 to R.sub.8 stands for hydrogen, or if R.sub.9 stands for a radical having at least 2 carbon atoms--for chlorine,R.sub.2 and R.sub.3, independent of one another, each stands for hydrogen, chlorine or alkyl of 1 to 4 carbon atoms,R.sub.4 stands for hydrogen, chlorine, alkyl of 1 to 4 carbon atoms, cyclopentyl, cyclohexyl, methylcyclohexyl or R.sub.3 and R.sub.4 together stand for a --CH.dbd.CH--CH.dbd.CH-- bridge,R.sub.5, R.sub.6 and R.sub.7, independent of one another, each stands for hydrogen or alkyl of 1 to 4 carbon atoms,R.sub.8 stands for hydrogen, alkyl of 1 to 4 carbon atoms or allyl,R.sub.9 stands for alkyl of 1 to 10 carbon atoms or phenyl andX stands for hydrogen, the cation of a physiologically acceptable inorganic or organic base of a hydrocarbon radical of 1 to 10 carbon atoms, having a strong action on the lipide and cholesterine metabolism and a process for their manufacture.

摘要翻译： R1代表氢，甲硫基，环戊基，环己基，苯基，甲基环己基，乙基环己基或R 1和R 3的新的4-苯氧基 - 苯氧基 - 烷 - 羧酸衍生物，其中R1代表氢，甲基， -CH = CH-桥或 - 除非取代基R2至R8中的至少一个代表氢，或者如果R9表示具有至少2个碳原子的基团，则对于氯，R 2和R 3彼此独立地，各自独立地 对于氢，氯或1至4个碳原子的烷基，R4代表氢，氯，1至4个碳原子的烷基，环戊基，环己基，甲基环己基或R3和R4一起代表-CH = CH-CH = CH- 桥，R5，R6和R7彼此独立，各代表氢或1-4个碳原子的烷基，R8代表氢，1-4个碳原子的烷基或烯丙基，R9代表1-10个碳原子的烷基 原子或苯基，X代表氢，生理上可接受的无机或有机碱的烃的阳离子 具有1至10个碳原子的基团，对脂质和胆固醇代谢具有强烈的作用及其制造方法。

公开(公告)号：US4301295A

公开(公告)日：1981-11-17

申请号：US179889

申请日：1980-08-20

申请人： Helmut Nahm ,  Ernold Granzer

发明人： Helmut Nahm ,  Ernold Granzer

IPC分类号： C07C51/09 ,  C07C59/68 ,  C07C69/736

CPC分类号： C07C59/68 ,  C07C51/09

摘要： Novel 4-phenoxy-phenoxy-alkane-carboxylic acid derivatives of the formula I ##STR1## in which R.sub.1 stands for hydrogen, methylthio, cyclopentyl, cyclohexyl, phenyl, methylcyclohexyl, ethylcyclohexyl, or R.sub.1 and R.sub.3 together stand for a --CH.dbd.CH--CH.dbd.CH-- bridge or--unless at least one of the substituents R.sub.2 to R.sub.8 stands for hydrogen, or if R.sub.9 stands for a radical having at least 2 carbon atoms--for chlorine,R.sub.2 and R.sub.3, independent of one another, each stands for hydrogen, chlorine or alkyl of 1 to 4 carbon atoms,R.sub.4 stands for hydrogen, chlorine, alkyl of 1 to 4 carbon atoms, cyclopentyl, cyclohexyl, methylcyclohexyl or R.sub.3 and R.sub.4 together stand for a --CH.dbd.CH--CH.dbd.CH-- bridge,R.sub.5, R.sub.6 and R.sub.7, independent of one another, each stands for hydrogen or alkyl of 1 to 4 carbon atoms,R.sub.8 stands for hydrogen, alkyl of 1 to 4 carbon atoms or allyl,R.sub.9 stands for alkyl of 1 to 10 carbon atoms or phenyl andX stands for hydrogen, the cation of a physiologically acceptable inorganic or organic base of a hydrocarbon radical of 1 to 10 carbon atoms, having a strong action on the lipide and cholesterine metabolism and a process for their manufacture.

摘要翻译： R1代表氢，甲硫基，环戊基，环己基，苯基，甲基环己基，乙基环己基或R 1和R 3的新的4-苯氧基 - 苯氧基 - 烷 - 羧酸衍生物代表-CH = CH -CH = CH-桥或 - 除非取代基R2至R8中的至少一个代表氢，或者如果R9表示具有至少2个碳原子的基团，则对于氯，R 2和R 3彼此独立地，各自独立地 对于氢，氯或1至4个碳原子的烷基，R4代表氢，氯，1至4个碳原子的烷基，环戊基，环己基，甲基环己基或R3和R4一起代表-CH = CH-CH = CH- 桥，R5，R6和R7彼此独立，各代表氢或1-4个碳原子的烷基，R8代表氢，1-4个碳原子的烷基或烯丙基，R9代表1-10个碳原子的烷基 原子或苯基，X代表氢，生理上可接受的无机或有机碱的烃的阳离子 具有1至10个碳原子的基团，对脂质和胆固醇代谢具有强烈的作用及其制造方法。

公开(公告)号：US4391995A

公开(公告)日：1983-07-05

申请号：US265902

申请日：1981-05-21

申请人： Helmut Nahm ,  Ernold Granzer

发明人： Helmut Nahm ,  Ernold Granzer

IPC分类号： A61K31/19 ,  C07C37/05 ,  C07C43/263 ,  C07C43/29 ,  C07C51/09 ,  C07C59/68 ,  C07C59/70 ,  C07C69/712 ,  C07C2/88

CPC分类号： C07C323/00 ,  C07C51/09 ,  C07C59/68

摘要： Novel 4-phenoxy-phenoxy-alkane-carboxylic acid derivatives of the formula I ##STR1## in which R.sub.1 stands for hydrogen, methylithio, cyclopentyl, cyclohexyl, phenyl, methylcycylohexyl, ethylcyclohexyl, or R.sub.1 and R.sub.3 together stand for a --CH.dbd.CH--CH.dbd.CH-- bridge or--unless at least one of the substituents R.sub.2 to R.sub.8 stands for hydrogen, or if R.sub.9 stands for a radical having at least 2 carbon atoms--for chlorine,R.sub.2 and R.sub.3, independent of one another, each stands for hydrogen, chlorine or alkyl of 1 to 4 carbon atoms,R.sub.4 stands for hydrogen, chlorine, alkyl of 1 to 4 carbon atoms, cyclopentyl, cyclohexyl, methylcyclohexyl or R.sub.3 and R.sub.4 together stand for a --CH.dbd.CH--CH.dbd.CH-- bridge,R.sub.5, R.sub.6 and R.sub.7, independent of one another, each stands for hydrogen or alkyl of 1 to 4 carbon atoms,R.sub.8 stands for hydrogen, alkyl of 1 to 4 carbon atoms or allyl,R.sub.9 stands for alkyl of 1 to 10 carbon atoms or phenyl andX stands for hydrogen, the cation of a physiologically acceptable inorganic or organic base of a hydrocarbon radical of 1 to 10 carbon atoms, having a strong action on the lipide and cholesterine metabolism and a process for this manufacture.

摘要翻译： 式I的新型4-苯氧基 - 苯氧基 - 烷 - 羧酸衍生物，其中R1代表氢，甲硫基，环戊基，环己基，苯基，甲基氰基己基，乙基环己基或R1和R3一起代表-CH = CH -CH = CH-桥或 - 除非取代基R2至R8中的至少一个代表氢，或者如果R9表示具有至少2个碳原子的基团，则对于氯，R 2和R 3彼此独立地，各自独立地 对于氢，氯或1至4个碳原子的烷基，R4代表氢，氯，1至4个碳原子的烷基，环戊基，环己基，甲基环己基或R3和R4一起代表-CH = CH-CH = CH- 桥，R5，R6和R7彼此独立，各代表氢或1-4个碳原子的烷基，R8代表氢，1-4个碳原子的烷基或烯丙基，R9代表1-10个碳原子的烷基 原子或苯基，X代表氢，生物学上可接受的无机或有机碱基的阳离子 具有1至10个碳原子的自由基，对脂质和胆固醇代谢具有强烈的作用和用于该制造的方法。

公开(公告)号：US3954442A

公开(公告)日：1976-05-04

申请号：US359274

申请日：1973-05-11

申请人： Werner Becker ,  Peter Langeluddeke ,  Heinrich Leditschke ,  Helmut Nahm ,  Friedhelm Schwerdtle

发明人： Werner Becker ,  Peter Langeluddeke ,  Heinrich Leditschke ,  Helmut Nahm ,  Friedhelm Schwerdtle

IPC分类号： C07C69/712 ,  A01N37/02 ,  A01N37/38 ,  A01N37/44 ,  A01N39/02 ,  A01N39/04 ,  A01P13/00 ,  C07C41/00 ,  C07C43/205 ,  C07C43/225 ,  C07C51/00 ,  C07C51/09 ,  C07C59/125 ,  C07C59/68 ,  C07C59/70 ,  C07C67/00 ,  C07C69/76 ,  C07C231/00 ,  C07C233/00 ,  C07C233/45 ,  C07C235/20 ,  C07C235/24 ,  C07C239/00 ,  C07C239/20 ,  C07C259/06 ,  C07C313/00 ,  C07C323/20 ,  C07C323/22 ,  C07C325/00 ,  C07C327/20 ,  C07C327/22 ,  C07D213/63 ,  C07D213/64 ,  A01N9/24

CPC分类号： C07D213/63 ,  C07C321/00 ,  C07C323/00 ,  C07C327/00 ,  C07C51/09 ,  C07C59/68

摘要： Compounds of the formula I ##SPC1##in which R represents hydrogen, halogen, alkyl having 1 to 4 carbon atoms, alkoxy and alkylthio having 1 to 4 carbon atoms, cyclohexyl, cyclopentyl, and phenyl, R.sup.1 represents hydrogen, halogen, alkyl having 1 to 4 carbon atoms, and alkenyl having 2 to 4 carbon atoms, X and Y each are oxygen or sulfur, R.sup.2 represents hydrogen, alkyl having 1 to 10 carbon atoms, alkoxyalkyl having 2 to 6 carbon atoms, alkyl-amino having 2 to 4 carbon atoms, or phenyl, R.sup.3 represents hydrogen or alkyl having 1 to 4 carbon atoms, R.sup.4 represents hydroxyl, --O-alkyl having 1 to 10 carbon atoms, --S-alkyl having 1 to 6 carbon atoms, --O-- alkenyl having 2 to 4 carbon atoms, --O-cyclohexyl, --O-cyclopentyl, a phenoxy or phenylthio radical optionally substituted once or twice with halogen; --NH.sub.2, --NH-alkyl having 1 to 4 carbon atoms, --N,N-dialkyl or ##EQU1## HAVING 1 TO 4 CARBON ATOMS IN EACH ALKYL GROUP, A --NH-phenyl radical substituted with halogen, --CF.sub.3, --OCF.sub.2 CF.sub.2 H, or --COOCH.sub.3, or --O-benzyl, or --NH-benzyl, or --S-benzyl, or --O-cat. wherein cat. stands for the cation of an inorganic or organic base, are valuable selective herbicides.

摘要翻译： 其中R表示氢，卤素，具有1至4个碳原子的烷基，烷氧基和具有1至4个碳原子的烷硫基的式I化合物，环己基，环戊基和苯基，R 1表示氢，卤素，具有1至4个碳原子的烷基 原子和具有2至4个碳原子的烯基，X和Y各自为氧或硫，R 2表示氢，具有1至10个碳原子的烷基，具有2至6个碳原子的烷氧基烷基，具有2至4个碳原子的烷基 - 或苯基，R 3表示氢或具有1至4个碳原子的烷基，R 4表示羟基，具有1至10个碳原子的-O-烷基，具有1至6个碳原子的-S-烷基，具有2至4个碳原子的-O-链烯基 原子，-O-环己基，-O-环戊基，苯氧基或苯硫基，其任选被卤素取代一次或两次; -NH 2，具有1至4个碳原子的-NH-烷基，-N，N-二烷基或烷基N烷基O-烷基，具有每个烷基中的1至4个碳原子，被卤素-CF 3取代的-NH-苯基 ，-OCF 2 CF 2 H或-COOCH 3，或-O-苄基或-NH-苄基，或-S-苄基或-O-氨基。 其中猫 代表无机或有机碱的阳离子，是有价值的选择性除草剂。