发明授权
US4411908A Imidazoline derivatives as presynaptic .alpha..sub.2 -adrenoreceptor
antagonists
失效
咪唑啉衍生物作为突触前α2肾上腺素受体拮抗剂
- 专利标题： Imidazoline derivatives as presynaptic .alpha..sub.2 -adrenoreceptor antagonists
- 专利标题（中）： 咪唑啉衍生物作为突触前α2肾上腺素受体拮抗剂
-
申请号： US397686申请日： 1982-07-13
-
公开(公告)号： US4411908A公开(公告)日： 1983-10-25
- 发明人: Christopher B. Chapleo , Peter L. Myers
- 申请人： Christopher B. Chapleo , Peter L. Myers
- 申请人地址： GB2 London
- 专利权人： Reckitt & Colman Products Limited
- 当前专利权人： Reckitt & Colman Products Limited
- 当前专利权人地址： GB2 London
- 优先权： GBX8123271 19810728
- 主分类号： A61K31/341
- IPC分类号： A61K31/341 ; A61K31/415 ; A61K31/4178 ; A61P9/06 ; A61P25/02 ; A61P25/04 ; A61P25/06 ; A61P25/24 ; A61P25/26 ; C07D303/14 ; C07D307/80 ; C07D307/85 ; C07D405/04
摘要：
Imidazoline derivatives of the formula ##STR1## wherein R.sup.1 is hydrogen or alkyl C.sub.1-6 ;R.sup.2 is hydrogen, methyl, chloro, bromo or fluoro;R.sup.3 is hydrogen, methyl, hydroxy, methoxy, fluoro, chloro or bromo; and their non-toxic salts.Processes for their preparation and pharmaceutical compositions thereof. The compounds exhibit presynaptic .alpha..sub.2 -adrenoreceptor antagonist activity.