发明授权
US4424344A 2-N-Acylated and 2-N-alkylated derivatives of
4-O-substituted-2-deoxystreptamine aminoglycosides and process
失效
4-O-取代-2-脱氧神经氨酸糖苷类的2-N-酰化和2-N-烷基化衍生物和方法
- 专利标题： 2-N-Acylated and 2-N-alkylated derivatives of 4-O-substituted-2-deoxystreptamine aminoglycosides and process
- 专利标题（中）： 4-O-取代-2-脱氧神经氨酸糖苷类的2-N-酰化和2-N-烷基化衍生物和方法
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申请号： US304292申请日： 1981-09-21
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公开(公告)号： US4424344A公开(公告)日： 1984-01-03
- 发明人: Herbert A. Kirst , Brenda A. Truedell
- 申请人： Herbert A. Kirst , Brenda A. Truedell
- 申请人地址： IN Indianapolis
- 专利权人： Eli Lilly and Company
- 当前专利权人： Eli Lilly and Company
- 当前专利权人地址： IN Indianapolis
- 主分类号： C07D207/40
- IPC分类号： C07D207/40 ; C07D207/416 ; C07H15/224 ; C07H15/22
摘要：
Nickel salts are used to effect the regio-selective acylation and alkylation of the 2'-amino group of 4-O-substituted-2-deoxystreptamine containing aminoglycosides. The 2'-N-substituted derivatives of apramycin, certain .alpha. or .beta.-(lower alkyl)aprosaminides and certain .alpha. or .beta.-(substituted lower alkyl)aprosaminides are new. The 2'-N-substituted-4-O-substituted-2-deoxystreptamine aminoglycosides produced by the process of this invention are antibacterial agents.
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