发明授权
US4431627A Gamma-emitting receptor-binding 3-quinuclidinyl glycolates; methods of
preparation thereof and imaging and assay methods utilizing same
失效
发光受体结合3-奎宁环酸乙二醇酯; 其制备方法和利用其的成像和测定方法
- 专利标题： Gamma-emitting receptor-binding 3-quinuclidinyl glycolates; methods of preparation thereof and imaging and assay methods utilizing same
- 专利标题（中）： 发光受体结合3-奎宁环酸乙二醇酯; 其制备方法和利用其的成像和测定方法
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申请号： US336340申请日： 1981-12-31
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公开(公告)号： US4431627A公开(公告)日： 1984-02-14
- 发明人: William C. Eckelman , Richard C. Reba , Waclaw J. Rzeszotarski , Raymond E. Gibson
- 申请人： William C. Eckelman , Richard C. Reba , Waclaw J. Rzeszotarski , Raymond E. Gibson
- 申请人地址： NY New York
- 专利权人： Research Corporation
- 当前专利权人： Research Corporation
- 当前专利权人地址： NY New York
- 主分类号： A61K51/00
- IPC分类号： A61K51/00 ; A61K51/04 ; C07D453/00 ; C07D453/02 ; G01N33/60 ; A61K49/00 ; A61K43/00 ; G01N33/54
摘要：
Compounds of the formula: ##STR1## wherein R is aryl, alkyl, cycloalkyl, phenyl, cyclopentyl, cyclohexyl, a ligand containing Tc-99m in chelated form or a ligand capable of chelating Tc-99m;R.sub.1 is H or lower alkyl;X is in the ortho-, meta or para- position, and is selected from the group consisting of .sup.125 I, .sup.123 I, .sup.127 I, I, .sup.18 F, .sup.75 Br, .sup.77 Br, NH.sub.2, and ##STR2## wherein R.sub.2 is in the 2,3, or 4 position and is selected from the group consisting of H and lower alkyl, provided that when R is a ligand capable of chelating Tc-99m or containing Tc-99m in chelated form, X is not a radioisotope and may also be H or lower alkyl;Z.sup..crclbar. is an anion; or the free amine thereof; anddenotes an asymmetric carbon atom.