发明授权
- 专利标题: Aroyl-aminoacids, amides and esters thereof
- 专利标题(中): 芳酰氨基酸,酰胺和酯
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申请号: US219051申请日: 1980-12-22
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公开(公告)号: US4440941A公开(公告)日: 1984-04-03
- 发明人: John T. Suh , Paul R. Menard , Howard Jones
- 申请人: John T. Suh , Paul R. Menard , Howard Jones
- 申请人地址: NY Tarrytown
- 专利权人: USV Pharmaceutical Corporation
- 当前专利权人: USV Pharmaceutical Corporation
- 当前专利权人地址: NY Tarrytown
- 主分类号: A61K31/195
- IPC分类号: A61K31/195 ; A61K31/165 ; A61K31/22 ; A61P9/12 ; C07C20060101 ; C07C63/04 ; C07C67/00 ; C07C69/84 ; C07C231/02 ; C07C231/08 ; C07C233/12 ; C07C233/82 ; C07C235/52 ; C07C235/62 ; C07C235/84 ; C07C237/36 ; C07C237/38 ; C07C237/44 ; C07C253/00 ; C07C255/57 ; C07C301/00 ; C07C303/40 ; C07C311/29 ; C07C313/00 ; C07C315/04 ; C07C317/00 ; C07C317/46 ; C07C317/48 ; C07C317/50 ; C07C323/59 ; C07C323/60 ; C07C323/62 ; C07C323/65 ; C07C325/00 ; C07C327/22 ; C07C327/32 ; C07D207/16 ; C07D213/75 ; C07D215/38 ; C07D295/08 ; C07D307/52 ; C07D307/70 ; C07D333/36 ; C07K5/02
摘要:
Compounds of the structure ##STR1## wherein: Q is oxygen, sulfur or imino.X and Y are hydrogen, halogen, hydroxy, alkoxy, trifluoromethyl, nitro, carboxy, cyano, sulfonamido, sulfhydryl, alkyl, alkenyl, alkynyl, alkanoyl, alkylmercapto, amino, alkylamino, dialkylamino, alkysulfinyl, and alkylsulfonyl and may be the same or different;R.sub.1 is hydrogen, alkanoyl, substituted alkanoyl wherein the substituent is hydroxy, amino or cycloalkyl, aroyl, arylalkanoyl, or cycloalkylcarbonyl,n is an integer from 1 to 4 inclusive,R.sub.2 and R.sub.3 are hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, aryl, aralkyl, and substituted derivatives thereof wherein the substituents are hydroxy, amino, alkylamino, dialkylamino, alkoxy, halogen, hydroxy, mercapto, alkylmercapto and nitro, and may be the same or different;M is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl, and hetero; andZ is hydroxy, amino, alkylamino, dialkylamino, or alkoxy,have angiotensin converting enzyme inhibitory activity.
公开/授权文献
- US6067831A Hydroforming process 公开/授权日:2000-05-30