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    Antihypertensive lactams
    3.
    发明授权
    Antihypertensive lactams 失效
    抗高血压内酰胺

    公开(公告)号：US4766210A

    公开(公告)日：1988-08-23

    申请号：US288134

    申请日：1981-07-29

    申请人： John T. Suh ,  Bruce E. Williams ,  Jerry W. Skiles ,  Bernard Loev

    发明人： John T. Suh ,  Bruce E. Williams ,  Jerry W. Skiles ,  Bernard Loev

    IPC分类号： C07D277/06 ,  C07D279/12 ,  C07D281/06 ,  C07D513/04

    CPC分类号： C07D513/04 ,  C07D277/06 ,  C07D279/12 ,  C07D281/06

    摘要： Antihypertensive compounds of the structure ##STR1## wherein: n is an integer from 0 to 2 inclusive,R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, and R.sub.7 are independently hydrogen, alkyl having from 1 to 6 carbon atoms, alkenyl having from 2 to 6 carbon atoms, alkynyl having from 2 to 6 carbon atoms, cycloalkyl having from 3 to 16 carbon atoms, phenyl, benzyl, tolyl, naphthyl, phenethyl, indanyl, tetrahydronaphthyl, decahydronaphthyl, pyridyl, quinolyl, pyrrolidyl, pyrrolyl, morpholinyl, thiomorpholinyl, furyl, furfuryl, tetrahydrofurfuryl, benzimidazole, thienyl, imidolyl, or tetrahydroindolyl, and where the R.sub.1 to R.sub.7 groups are alkyl, said groups carrying a substituent selected from hydroxy, alkoxy, amino, carboxy, or carbalkoxy, the alkyl group in alkoxy and carbalkoxy having from 1 to 6 carbon atoms, or R.sub.2 taken together with R.sub.3 and the carbons to which they are attached is tetrahydronapthyl or phenyl, and when phenyl R.sub.1 and R.sub.4 are absent, or R.sub.6 and R.sub.7 taken together with the carbon to which R.sub.6 is attached and the nitrogen to which R.sub.7 is attached form a heterocycle selected from pyrrolidyl, thiazolidine, tetrahydro-isoquinoline, thiomorpholine, or 2,2,5,5-tetramethylthiazolidinie, andY is .dbd.O, .dbd.S, .dbd.NR.sub.1, .dbd.NOR.sub.1 or .dbd.N--NH.sub.2, R.sub.1 being the same as defined above.

    摘要翻译： 结构的抗高血压化合物其中：n为0〜2的整数，R1，R2，R3，R4，R5，R6和R7独立地为氢，具有1-6个碳原子的烷基， 2至6个碳原子，具有2至6个碳原子的炔基，具有3至16个碳原子的环烷基，苯基，苄基，甲苯基，萘基，苯乙基，茚满基，四氢萘基，十氢萘基，吡啶基，喹啉基，吡咯烷基，吡咯基，吗啉基， 硫代吗啉基，呋喃基，糠基，四氢糠基，苯并咪唑，噻吩基，亚氨基或四氢吲哚基，其中R 1至R 7基团是烷基，所述基团含有选自羟基，烷氧基，氨基，羧基或烷氧基的取代基，烷氧基 和具有1至6个碳原子的烷氧基，或者R 2与R 3和它们所连接的碳一起是四氢萘基或苯基，当R 1和R 4不存在时，或者R 6和R 7与R 6一起 附上 并且R 7连接的氮形成选自吡咯烷基，噻唑烷，四氢 - 异喹啉，硫代吗啉或2,2,5,5-四甲基噻唑烷的杂环，Y = O，= S，= NR1，= NOR1或 = N-NH 2，R 1与上述定义相同。