发明授权
US4482562A Aromatic aminoethanol compounds, and utilization thereof as
cardiovascular agents
失效
芳香族氨基乙醇化合物及其作为心血管药物的用途
- 专利标题: Aromatic aminoethanol compounds, and utilization thereof as cardiovascular agents
- 专利标题(中): 芳香族氨基乙醇化合物及其作为心血管药物的用途
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申请号: US414819申请日: 1982-09-03
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公开(公告)号: US4482562A公开(公告)日: 1984-11-13
- 发明人: Masami Shiratsuchi , Noboru Shimizu , Hiromichi Shigyo , Yoshinori Kyotani , Hisashi Kunieda , Kiyoshi Kawamura , Seiichi Sato , Toshihiro Akashi , Masahiko Nagakura , Naotoshi Sawada , Yasumi Uchida
- 申请人: Masami Shiratsuchi , Noboru Shimizu , Hiromichi Shigyo , Yoshinori Kyotani , Hisashi Kunieda , Kiyoshi Kawamura , Seiichi Sato , Toshihiro Akashi , Masahiko Nagakura , Naotoshi Sawada , Yasumi Uchida
- 申请人地址: JPX Aichi
- 专利权人: Kowa Company, Ltd.
- 当前专利权人: Kowa Company, Ltd.
- 当前专利权人地址: JPX Aichi
- 优先权: JPX55-15433 19800213
- 主分类号: A61K31/21
- IPC分类号: A61K31/21 ; A61K31/135 ; A61K31/165 ; A61K31/44 ; A61K31/4402 ; A61K31/4418 ; A61P9/00 ; A61P9/12 ; A61P25/02 ; A61P25/28 ; C07C67/00 ; C07C203/04 ; C07C213/00 ; C07C217/32 ; C07C217/70 ; C07C219/16 ; C07C219/34 ; C07C225/16 ; C07C231/00 ; C07C231/12 ; C07C235/42 ; C07C235/46 ; C07C237/30 ; C07C301/00 ; C07C303/40 ; C07C311/17 ; C07C311/29 ; C07C313/00 ; C07C315/04 ; C07C317/22 ; C07C317/24 ; C07C317/32 ; C07C319/20 ; C07C323/25 ; C07D213/30 ; C07D213/60 ; C07D213/64 ; C07D213/69 ; C07D303/24 ; C07D303/26 ; C07D309/12 ; C07D213/74
摘要:
A compound represented by the following formula ##STR1## wherein A represents a direct bond or the bond --O--CH.sub.2 --,B represents a C.sub.1 -C.sub.11 alkylene group bonded to a carbon atom of the aromatic ring D either directly or through --O--, --S--, --SO-- or --NH--,W represents a carbon or nitrogen atom,R.sub.1 represents a C.sub.3 -C.sub.7 alkyl group, a hydroxy-C.sub.1 -C.sub.6 alkyl group, or a phenyl- or diphenyl-alkyl group with the alkyl group having 1 to 4 carbon atoms,R.sub.2 represents a member selected from the group consisting of hydrogen, halogen, OH, C.sub.1 -C.sub.4 alkyl, NO.sub.2, C.sub.1 -C.sub.4 alkoxy, acetyl, allyloxy, carbamoyl and sulfamoyl, and when two or more R.sub.2 groups exist, they may be identical or different, andn represents 1, 2 or 3 and m represents 1 or 2, provided that n+m.gtoreq.4;and an acid addition salt thereof; a process for producing the same; and a pharmaceutical composition comprising aforesaid compound.
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