发明授权
- 专利标题： Creatinine specific antibody
- 专利标题（中）： 肌酸酐特异性抗体
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申请号： US412411申请日： 1982-08-27
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公开(公告)号： US4485177A公开(公告)日： 1984-11-27
- 发明人: Joachim Siedel , Ulrich Neumann , Joachim Ziegenhorn , Hans-George Batz , Helmut Lenz , Brigitte Pautz , Winfried Albert
- 申请人： Joachim Siedel , Ulrich Neumann , Joachim Ziegenhorn , Hans-George Batz , Helmut Lenz , Brigitte Pautz , Winfried Albert
- 申请人地址： DEX Mannheim-Waldhof
- 专利权人： Boehringer Mannheim GmbH
- 当前专利权人： Boehringer Mannheim GmbH
- 当前专利权人地址： DEX Mannheim-Waldhof
- 优先权： DEX3134787 19810902
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; A61K38/00 ; C07K16/18 ; G01N33/531 ; G01N33/543 ; G01N33/577 ; G01N33/70 ; G01N33/54 ; A61K39/00 ; C07G7/00
摘要：
The present invention provides a creatinine antibody and a process for the preparation thereof, wherein a conjugate of creatinine and a material suitable for antiserum formation, which are connected via an aliphatic or araliphatic carboxylic acid as bridge member, is used as immunogen for antiserum formation.The present invention is also concerned with the use of the above antibody for the immunological determination of creatinine, wherein the antibody is incubated with a creatinine-containing sample solution, reacted with a conjugate of creatinine with a hapten carrier substance, whereby one of the components, antibody and conjugate, is present in the solid phase or in dissolved form and the other component is present in dissolved form and the inhibition of the binding reaction between the antibody and the creatinine conjugate is measured.Furthermore, the present invention provides a reagent for the immunological determination of creatinine, wherein it contains the above antibody, a conjugate of creatinine with a hapten carrier substance and buffer substance.
公开/授权文献
- US5277875A Self-contained sterilizer with duty-cycle heater 公开/授权日：1994-01-11
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