发明授权
US4547514A Aryloxy-N-(aminoalkyl)-1-pyrrolidine and piperidine carboxamides and
carbothioamides having antiarrhythmic activity
失效
丙烯酰氧基-N-(氨基烷基)-1-吡咯烷和哌啶甲酰胺和具有抗心律失常活性的硫代酰胺
- 专利标题: Aryloxy-N-(aminoalkyl)-1-pyrrolidine and piperidine carboxamides and carbothioamides having antiarrhythmic activity
- 专利标题(中): 丙烯酰氧基-N-(氨基烷基)-1-吡咯烷和哌啶甲酰胺和具有抗心律失常活性的硫代酰胺
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申请号: US557885申请日: 1983-12-05
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公开(公告)号: US4547514A公开(公告)日: 1985-10-15
- 发明人: Pershottam P. Mathur , William L. Smith
- 申请人: Pershottam P. Mathur , William L. Smith
- 申请人地址: VA Richmond
- 专利权人: A. H. Robins Company, Incorporated
- 当前专利权人: A. H. Robins Company, Incorporated
- 当前专利权人地址: VA Richmond
- 主分类号: A61K31/40
- IPC分类号: A61K31/40 ; A61K31/445 ; A61P9/06 ; C07D207/12 ; C07D211/40 ; C07D211/42 ; C07D211/46 ; A61K31/385 ; A61K31/495 ; A61K31/535
摘要:
Pharmaceutical compositions comprised of aryloxy-N-(aminoalkyl)-1-pyrrolidine and piperidine carboxamides and carbothioamides are provided of the formula: ##STR1## wherein Ar is selected from the group consisting of 1-naphthyl, 2-naphthyl, 2,3-dihydro-1H-inden-4-yl, 2,3-dihydro-1H-inden-5-yl, phenyl, substituted phenyl wherein the substituents are selected from lower alkyl of from 1 to 8 carbon atoms, lower alkyloxy of from 1 to 8 carbon atoms, halogen and trifluoromethyl; m and n are 1 or 2 but are never 2 at the same time; p is 1, 2, 3 or 4; R is selected from hydrogen or lower alkyl of from 1 to 3 carbon atoms; R.sup.1 and R.sup.2 are selected from hydrogen, lower alkyl of from 1 to 8 carbon atoms, phenyl, phenyl lower alkyl of from 7 to 9 carbon atoms, and cycloalkyl of from 3 to 8 carbon atoms, and R.sup.1 and R.sup.2 taken together with the adjacent atom may form a heterocyclic residue selected from 4-morpholino, 1-pyrrolidino, 1-piperidino, 1-piperazino and 4-lower alkyl piperazin-1-yl; X is oxygen or sulfur; and the pharmaceutically acceptable acid addition salts thereof having antiarrhythmic activity.
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