发明授权
US4565789A Cell matrix receptor system and use in cancer diagnosis and management
失效
细胞基质受体系统用于癌症诊断和治疗
- 专利标题： Cell matrix receptor system and use in cancer diagnosis and management
- 专利标题（中）： 细胞基质受体系统用于癌症诊断和治疗
-
申请号： US481934申请日： 1983-04-04
-
公开(公告)号： US4565789A公开(公告)日： 1986-01-21
- 发明人: Lance A. Liotta , Nageswara C. Rao , Victor Terranova
- 申请人： Lance A. Liotta , Nageswara C. Rao , Victor Terranova
- 申请人地址： DC Washington
- 专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人地址： DC Washington
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K39/00 ; A61K39/395 ; A61P35/00 ; G01N33/15 ; G01N33/53 ; G01N33/566 ; G01N33/574 ; G01N33/58 ; G01N33/60 ; G01N33/50 ; G01N33/534 ; G01N33/567
摘要：
A cell matrix receptor specific for laminin expressed on the surface of carcinoma and epithelial cells is provided. The binding of these cells to extracellular matrix is mediated by the laminin molecule, which has binding domains for type IV collagen of the matrix and the cell surface receptor. Fragments of the laminin molecule lacking the type IV collagen binding domain and antibodies to the receptor are useful in conjunction with the cell receptor as ligands in binding assays for cancer diagnosis and in cancer management.
公开/授权文献
信息查询
IPC分类:
