发明授权
US4565817A Theophyllinyl-alkyl-oxadiazoles, process for the preparation thereof and
pharmaceutical compositions containing same
失效
木脂基 - 烷基 - 恶二唑,其制备方法和含有它们的药物组合物
- 专利标题: Theophyllinyl-alkyl-oxadiazoles, process for the preparation thereof and pharmaceutical compositions containing same
- 专利标题(中): 木脂基 - 烷基 - 恶二唑,其制备方法和含有它们的药物组合物
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申请号: US474227申请日: 1983-03-11
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公开(公告)号: US4565817A公开(公告)日: 1986-01-21
- 发明人: Dezso Korbonits , Maria Szomor nee Wundele , Gergely Heja , Ida Szvoboda nee Kanzel , Pal Kiss , Csaba Gonczi , Endre Palosi , Gabor Kovacs , Judit Kun , Emil Minker , Sandor Virag , Gyula Sebestyen , Tamas Szuts
- 申请人: Dezso Korbonits , Maria Szomor nee Wundele , Gergely Heja , Ida Szvoboda nee Kanzel , Pal Kiss , Csaba Gonczi , Endre Palosi , Gabor Kovacs , Judit Kun , Emil Minker , Sandor Virag , Gyula Sebestyen , Tamas Szuts
- 申请人地址: HUX Budapest
- 专利权人: Chinoin Gyogyszer-es Vegyeszeti Termekek Gyara R.T.
- 当前专利权人: Chinoin Gyogyszer-es Vegyeszeti Termekek Gyara R.T.
- 当前专利权人地址: HUX Budapest
- 优先权: HUX762/82 19821203
- 主分类号: C07D413/06
- IPC分类号: C07D413/06 ; A61K31/52 ; A61K31/522 ; A61P11/00 ; A61P11/08 ; A61P11/14 ; A61P29/00 ; A61P31/14 ; C07D20060101 ; C07D271/06 ; C07D401/14 ; C07D473/08 ; C07D473/14 ; C07D473/10
摘要:
Antitussive compounds of the formula I ##STR1## or physiologically acceptable acid addition salts thereof are disclosed, where A stands for straight or branched chain C.sub.1-5 alkylene or ##STR2## R.sub.1 stands for straight or branched chain C.sub.1-10 alkyl, halogenoalkyl, hydroxyalkyl, C.sub.5-6 cycloalkyl, vinyl, 2-ethoxyethyl, carbonylalkyl or aminoalkyl of the formula ##STR3## wherein R stands for hydrogen or methyl, n is 0 to 3,R.sub.2 stands for hydrogen or straight or branched chain alkyl,R.sub.3 stands for hydrogen or straight or branched chain alkyl or,R.sub.2 and R.sub.3 together with the nitrogen atom may form a 5-6 membered ring, which ring can optionally contain an oxygen or a second nitrogen atom, the latter, optionally substituted by methyl or,R.sub.1 can stand for a phenyl group of the formulaR.sub.4 R.sub.5 C.sub.6 H.sub.3 whereinR.sub.4 and R.sub.5 represent independently hydrogen, chlorine, hydroxy, methoxy, ethoxy, methyl or amino or,R.sub.1 may further stand for hydroxy, in this case the compound of the formula I may exist according to the conditions in the form of tautomers of the formula Ia ##STR4## and R.sub.1 may further stand for benzyl, 2,2-diphenylethyl or theophyllin-7-yl-methyl.
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