发明授权
US4567002A Process for the preparation of 17-haloethynyl steroids, and novel
17-haloethynyl steroids
失效
制备17-卤代乙炔基类固醇和新型17-卤代乙炔基类固醇的方法
- 专利标题： Process for the preparation of 17-haloethynyl steroids, and novel 17-haloethynyl steroids
- 专利标题（中）： 制备17-卤代乙炔基类固醇和新型17-卤代乙炔基类固醇的方法
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申请号： US603855申请日： 1984-04-25
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公开(公告)号： US4567002A公开(公告)日： 1986-01-28
- 发明人: Helmut Hofmeister , Henry Laurent , Klaus Annen , Rudolf Wiechert
- 申请人： Helmut Hofmeister , Henry Laurent , Klaus Annen , Rudolf Wiechert
- 申请人地址： DEX Berlin and Bergkamen
- 专利权人： Schering Aktiengesellschaft
- 当前专利权人： Schering Aktiengesellschaft
- 当前专利权人地址： DEX Berlin and Bergkamen
- 优先权： DEX3315324 19830425
- 主分类号： C07J1/00
- IPC分类号： C07J1/00 ; C07J5/00 ; C07J7/00 ; C07J17/00 ; C07J41/00 ; C07J51/00 ; C07J53/00 ; C07J63/00
摘要：
17-haloethynyl steroids of the partial formula ##STR1## wherein R.sub.1 is hydrogen or methyl,R.sub.2 is alkyl of 1-4 carbon atoms, acyl of 1-7 carbon atoms, trimethylsilyl, 2-tetrahydropyranyl, or nitrate,X is bromine or iodine, andV is methylene, ethylene, vinylene, ethylidene, vinylidene or cyclopropylene,can be prepared by treating an ethynyl steroid of the partial formula ##STR2## wherein R.sub.1, R.sub.2, and V are as defined above, in an inert solvent with a brominating agent or an iodinating agent in the presence of a silver salt. Certain new compounds are also provided.
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