发明授权
- 专利标题： Substituted hexahydrobenzo[e]indene and octahydrophenanthrene CNS agents and pharmaceutical compositions thereof
- 专利标题（中）： 取代的六氢苯并[e]茚和八氢菲CNS剂及其药物组合物
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申请号： US618151申请日： 1984-06-07
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公开(公告)号： US4576964A公开(公告)日： 1986-03-18
- 发明人: James F. Eggler , Michael R. Johnson , Lawrence S. Melvin, Jr.
- 申请人： James F. Eggler , Michael R. Johnson , Lawrence S. Melvin, Jr.
- 申请人地址： NY New York
- 专利权人： Pfizer Inc.
- 当前专利权人： Pfizer Inc.
- 当前专利权人地址： NY New York
- 主分类号： C07C33/20
- IPC分类号： C07C33/20 ; C07C205/33 ; C07D207/08 ; C07D211/34 ; C07D307/10 ; C07D307/16 ; C07D309/04 ; C07D311/78 ; C07D455/04 ; C07D471/04 ; A61K31/22 ; C07C43/10 ; C07C43/205
摘要：
Tricyclic benzo fused compounds of the formula ##STR1## and pharmaceutically acceptable cationic and acid addition salts thereof, wherein n is zero, 1 or 2, and t is 1 or 2; M is CH or N, R.sub.1 is H or certain acyl groups; Q is CO.sub.2 R.sub.4, COR.sub.5, C(OR.sub.7)R.sub.5 R.sub.6, CN, CONR.sub.9 R.sub.10, CH.sub.2 NR.sub.9 R.sub.10, CH.sub.2 NHCOR.sub.11, CH.sub.2 NHSO.sub.2 R.sub.12, 5-tetrazolyl or when n is 1, Q and OR.sub.1 together form a lactone or certain reduced derivatives thereof; and Z is certain alkyl, alkoxy, alkoxyalkyl, aralkyl, aralkoxy, aryloxyalkyl or aralkoxyalkyl groups, are valuable central nervous system active agents, methods for their use, pharmaceutical compositions containing them and certain intermediates therefor.
公开/授权文献
- US5647430A Electronic component cooling unit 公开/授权日：1997-07-15