发明授权
US4579820A Process for enzymatic replacement of the B-30 amino acid in insulins
失效
在胰岛素中酶代替B-30氨基酸的方法
- 专利标题: Process for enzymatic replacement of the B-30 amino acid in insulins
- 专利标题(中): 在胰岛素中酶代替B-30氨基酸的方法
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申请号: US458847申请日: 1983-01-18
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公开(公告)号: US4579820A公开(公告)日: 1986-04-01
- 发明人: Klaus Breddam , Jack T. Johansen
- 申请人: Klaus Breddam , Jack T. Johansen
- 申请人地址: DKX Copenhagen
- 专利权人: De Forenede Bryggerier A/S
- 当前专利权人: De Forenede Bryggerier A/S
- 当前专利权人地址: DKX Copenhagen
- 优先权: DKX277/82 19820122
- 主分类号: A61K38/00
- IPC分类号: A61K38/00 ; C07K14/62 ; C12N9/50 ; C12P21/04 ; C12P21/06
摘要:
An insulin such as porcine insulin is reacted enzymatically with an L-amino acid, amide, or ester in the presence of L-specific serine carboxypeptidase modified by reaction with divalent metal ions in aqueous solution or dispersion containing F.sup.-, Cl.sup.-, Br.sup.-, I.sup.-, CN.sup.-, or SCN.sup.-.
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