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US4579820A Process for enzymatic replacement of the B-30 amino acid in insulins 失效
在胰岛素中酶代替B-30氨基酸的方法

Process for enzymatic replacement of the B-30 amino acid in insulins
摘要:
An insulin such as porcine insulin is reacted enzymatically with an L-amino acid, amide, or ester in the presence of L-specific serine carboxypeptidase modified by reaction with divalent metal ions in aqueous solution or dispersion containing F.sup.-, Cl.sup.-, Br.sup.-, I.sup.-, CN.sup.-, or SCN.sup.-.
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