发明授权
- 专利标题: Naphthalene anti-psoriatic agents
- 专利标题(中): 萘抗牛皮癣药
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申请号: US564155申请日: 1983-12-22
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公开(公告)号: US4593120A公开(公告)日: 1986-06-03
- 发明人: Gordon H. Jones , Michael C. Venuti , John M. Young
- 申请人: Gordon H. Jones , Michael C. Venuti , John M. Young
- 申请人地址: CA Palo Alto
- 专利权人: Syntex (U.S.A.) Inc.
- 当前专利权人: Syntex (U.S.A.) Inc.
- 当前专利权人地址: CA Palo Alto
- 主分类号: A61K31/215
- IPC分类号: A61K31/215 ; A61K31/22 ; A61K31/235 ; A61K31/265 ; A61K31/275 ; A61P17/00 ; A61P29/00 ; C07C45/63 ; C07C46/00 ; C07C46/02 ; C07C50/24 ; C07C50/32 ; C07C67/00 ; C07C69/017 ; C07C69/76 ; C07C69/78 ; C07C205/48 ; C07C213/00 ; C07C219/34 ; C07C253/00 ; C07C255/55 ; C07C313/00 ; C07C317/22 ; C07C323/20 ; C07C323/38 ; C07D213/70 ; C07D213/71 ; C07D213/89 ; C07D521/00
摘要:
Psoriasis in mammals is relieved by topically administering naphthalenes of the formula: ##STR1## wherein: R.sup.1 and R.sup.2 are the same and are lower alkoxy, lower alkylthio, optionally substituted phenoxy or optionally substituted phenylthio,R.sup.3 is lower alkyl, lower alkoxy, or halo and m is 0, 1 or 2 or R.sup.3 is optionally substituted phenyl, optionally substituted phenyl lower alkyl, optionally substituted phenyl lower alkoxy, amino, lower alkylamino, lower dialkylamino, cyano, or S(O).sub.n R wherein R is lower alkyl; optionally substituted phenyl; optionally substituted phenyl lower alkyl; or optionally substituted heterocyclic aryl of three to nine ring atoms containing one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, and the pharmaceutically acceptable acid addition salts thereof; and m is 1 and n is 0, 1 or 2; andW is alkyl of one to seven carbon atoms, optionally substituted phenyl or optionally substituted benzyl.
公开/授权文献
- US5741800A Azolyl-cyclic amine derivates with immunomodulatory activity 公开/授权日:1998-04-21
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